| RRC ID |
5639
|
| 著者 |
Ribaya JP, Ranmuthu M, Copeland J, Boyarskiy S, Blair AP, Hay B, Laski FA.
|
| タイトル |
The deubiquitinase emperor's thumb is a regulator of apoptosis in Drosophila.
|
| ジャーナル |
Dev Biol
|
| Abstract |
We have characterized the gene emperor's thumb (et) and showed that it is required for the regulation of apoptosis in Drosophila. Loss-of-function mutations in et result in apoptosis associated with a decrease in the concentration of DIAP1. Overexpression of one form of et inhibits apoptosis, consistent with et having an anti-apoptotic function; however, overexpression of a second form of et induces apoptosis, indicating that the two forms of et may have competing functions. et encodes a protein deubiquitinase, suggesting it regulates apoptosis by controlling the stability of apoptotic regulatory proteins.
|
| 巻・号 |
329(1)
|
| ページ |
25-35
|
| 公開日 |
2009-5-1
|
| DOI |
10.1016/j.ydbio.2009.02.005
|
| PII |
S0012-1606(09)00107-9
|
| PMID |
19217892
|
| MeSH |
Amino Acid Sequence
Animals
Apoptosis / physiology*
Apoptosis Regulatory Proteins / physiology*
Drosophila / genetics
Drosophila / metabolism*
Drosophila Proteins / physiology*
Endopeptidases / physiology*
Genes, Insect*
Models, Biological
Molecular Sequence Data
Mutation
Phylogeny
Protein Structure, Tertiary
Sequence Homology, Amino Acid
Ubiquitin-Protein Ligases / metabolism
|
| IF |
2.896
|
| 引用数 |
12
|
|
WOS 分野
|
DEVELOPMENTAL BIOLOGY
|
| リソース情報 |
| ショウジョウバエ |
|
