論文 - 詳細
| RRC ID | 5696 |
|---|---|
| 著者 | Shimada Y, Yonemura S, Ohkura H, Strutt D, Uemura T. |
| タイトル | Polarized transport of Frizzled along the planar microtubule arrays in Drosophila wing epithelium. |
| ジャーナル | Dev Cell |
| Abstract |
Cells in a variety of developmental contexts sense extracellular cues that are given locally on their surfaces, and subsequently amplify the initial signal to achieve cell polarization. Drosophila wing cells acquire planar polarity along the proximal-distal (P-D) axis, in which the amplification of the presumptive cue involves assembly of a multiprotein complex that spans distal and proximal boundaries of adjacent cells. Here we pursue the mechanisms that place one of the components, Frizzled (Fz), at the distal side. Intracellular particles of GFP-tagged Fz moved preferentially toward distal boundaries before Fz::GFP and other components were tightly localized at the P/D cortex. Arrays of microtubules (MTs) were approximately oriented along the P-D axis and these MTs contributed to the formation of the cortical complex. Furthermore, there appeared to be a bias in the P-D MTs, with slightly more plus ends oriented distally. The hypothesis of polarized vesicular trafficking of Fz is discussed. |
| 巻・号 | 10(2) |
| ページ | 209-22 |
| 公開日 | 2006-2-1 |
| DOI | 10.1016/j.devcel.2005.11.016 |
| PII | S1534-5807(05)00476-4 |
| PMID | 16459300 |
| MeSH | Adaptor Proteins, Signal Transducing Adherens Junctions / metabolism Animals Animals, Genetically Modified Biological Transport, Active Cadherins / metabolism Cell Polarity Dishevelled Proteins Drosophila / cytology* Drosophila / genetics Drosophila / metabolism* Drosophila Proteins / genetics Drosophila Proteins / metabolism* Epithelial Cells / cytology Epithelial Cells / metabolism Frizzled Receptors Genes, Insect Green Fluorescent Proteins / genetics Green Fluorescent Proteins / metabolism Membrane Proteins / genetics Membrane Proteins / metabolism* Microscopy, Electron Microtubules / metabolism Models, Biological Mutation Phosphoproteins / metabolism Pupa / cytology Pupa / metabolism Receptors, G-Protein-Coupled Recombinant Fusion Proteins / genetics Recombinant Fusion Proteins / metabolism Signal Transduction Wings, Animal / cytology Wings, Animal / metabolism |
| IF | 10.092 |
| 引用数 | 190 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | F1000Research |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
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