RRC ID |
57334
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著者 |
Robin M, Issa AR, Santos CC, Napoletano F, Petitgas C, Chatelain G, Ruby M, Walter L, Birman S, Domingos PM, Calvi BR, Mollereau B.
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タイトル |
Drosophila p53 integrates the antagonism between autophagy and apoptosis in response to stress.
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ジャーナル |
Autophagy
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Abstract |
The tumor suppressor TP53/p53 is a known regulator of apoptosis and macroautophagy/autophagy. However, the molecular mechanism by which TP53 regulates 2 apparently incompatible processes remains unknown. We found that Drosophila lacking p53 displayed impaired autophagic flux, higher caspase activation and mortality in response to oxidative stress compared with wild-type flies. Moreover, autophagy and apoptosis were differentially regulated by the p53 (p53B) and ΔNp53 (p53A) isoforms: while the former induced autophagy in differentiated neurons, which protected against cell death, the latter inhibited autophagy by activating the caspases Dronc, Drice, and Dcp-1. Our results demonstrate that the differential use of p53 isoforms combined with the antagonism between apoptosis and autophagy ensures the generation of an appropriate p53 biological response to stress.
|
巻・号 |
15(5)
|
ページ |
771-784
|
公開日 |
2019-5-1
|
DOI |
10.1080/15548627.2018.1558001
|
PMID |
30563404
|
PMC |
PMC6526837
|
MeSH |
Animals
Animals, Genetically Modified
Apoptosis / genetics*
Autophagy / genetics*
Cells, Cultured
Drosophila melanogaster / genetics*
Drosophila melanogaster / physiology
Oxidative Stress / physiology*
Protein Isoforms / genetics
Protein Isoforms / physiology
Signal Transduction / genetics
Tumor Suppressor Protein p53 / genetics
Tumor Suppressor Protein p53 / physiology*
|
IF |
11.059
|
引用数 |
5
|
リソース情報 |
ショウジョウバエ |
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