論文 - 詳細
| RRC ID | 57334 |
|---|---|
| 著者 | Robin M, Issa AR, Santos CC, Napoletano F, Petitgas C, Chatelain G, Ruby M, Walter L, Birman S, Domingos PM, Calvi BR, Mollereau B. |
| タイトル | Drosophila p53 integrates the antagonism between autophagy and apoptosis in response to stress. |
| ジャーナル | Autophagy |
| Abstract |
The tumor suppressor TP53/p53 is a known regulator of apoptosis and macroautophagy/autophagy. However, the molecular mechanism by which TP53 regulates 2 apparently incompatible processes remains unknown. We found that Drosophila lacking p53 displayed impaired autophagic flux, higher caspase activation and mortality in response to oxidative stress compared with wild-type flies. Moreover, autophagy and apoptosis were differentially regulated by the p53 (p53B) and ΔNp53 (p53A) isoforms: while the former induced autophagy in differentiated neurons, which protected against cell death, the latter inhibited autophagy by activating the caspases Dronc, Drice, and Dcp-1. Our results demonstrate that the differential use of p53 isoforms combined with the antagonism between apoptosis and autophagy ensures the generation of an appropriate p53 biological response to stress. |
| 巻・号 | 15(5) |
| ページ | 771-784 |
| 公開日 | 2019-5-1 |
| DOI | 10.1080/15548627.2018.1558001 |
| PMID | 30563404 |
| PMC | PMC6526837 |
| MeSH | Animals Animals, Genetically Modified Apoptosis / genetics* Autophagy / genetics* Cells, Cultured Drosophila melanogaster / genetics* Drosophila melanogaster / physiology Oxidative Stress / physiology* Protein Isoforms / genetics Protein Isoforms / physiology Signal Transduction / genetics Tumor Suppressor Protein p53 / genetics Tumor Suppressor Protein p53 / physiology* |
| IF | 11.059 |
| 引用数 | 5 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 11 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | |