論文 - 詳細
| RRC ID | 5791 |
|---|---|
| 著者 | Michaelson D, Korta DZ, Capua Y, Hubbard EJ. |
| タイトル | Insulin signaling promotes germline proliferation in C. elegans. |
| ジャーナル | Development |
| Abstract |
Cell proliferation must be coordinated with cell fate specification during development, yet interactions among pathways that control these two critical aspects of development are not well understood. The coordination of cell fate specification and proliferation is particularly crucial during early germline development, when it impacts the establishment of stem/progenitor cell populations and ultimately the production of gametes. In C. elegans, insulin/IGF-like receptor (IIR) signaling has been implicated in fertility, but the basis for the fertility defect had not been previously characterized. We found that IIR signaling is required for robust larval germline proliferation, separate from its well-characterized role in preventing dauer entry. IIR signaling stimulates the larval germline cell cycle. This activity is distinct from Notch signaling, occurs in a predominantly germline-autonomous manner, and responds to somatic activity of ins-3 and ins-33, genes that encode putative insulin-like ligands. IIR signaling in this role acts through the canonical PI3K pathway, inhibiting DAF-16/FOXO. However, signaling from these ligands does not inhibit daf-16 in neurons nor in the intestine, two tissues previously implicated in other IIR roles. Our data are consistent with a model in which: (1) under replete reproductive conditions, the larval germline responds to insulin signaling to ensure robust germline proliferation that builds up the germline stem cell population; and (2) distinct insulin-like ligands contribute to different phenotypes by acting on IIR signaling in different tissues. |
| 巻・号 | 137(4) |
| ページ | 671-80 |
| 公開日 | 2010-2-1 |
| DOI | 10.1242/dev.042523 |
| PII | 137/4/671 |
| PMID | 20110332 |
| PMC | PMC2827619 |
| MeSH | Animals Animals, Genetically Modified Caenorhabditis elegans / embryology* Caenorhabditis elegans / genetics Caenorhabditis elegans / growth & development Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Cell Differentiation Cell Proliferation Cytokines / genetics Cytokines / metabolism Female Forkhead Transcription Factors Genes, Helminth Germ Cells / cytology Germ Cells / metabolism Insulin / metabolism* Larva / cytology Larva / metabolism Ligands Male Phenotype Phosphatidylinositol 3-Kinases / metabolism Receptor, Insulin / genetics Receptor, Insulin / metabolism Receptors, Notch / metabolism Receptors, Somatomedin / metabolism Signal Transduction Transcription Factors / genetics Transcription Factors / metabolism |
| IF | 5.611 |
| 引用数 | 117 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm2988 |