論文 - 詳細
| RRC ID | 58477 |
|---|---|
| 著者 | Soulé S, Mellottée L, Arab A, Chen C, Martin JR. |
| タイトル | Jouvence a small nucleolar RNA required in the gut extends lifespan in Drosophila. |
| ジャーナル | Nat Commun |
| Abstract |
Longevity is influenced by genetic and environmental factors, but the underlying mechanisms remain elusive. Here, we functionally characterise a Drosophila small nucleolar RNA (snoRNA), named jouvence whose loss of function reduces lifespan. The genomic region of jouvence rescues the longevity in mutant, while its overexpression in wild-type increases lifespan. Jouvence is required in enterocytes. In mutant, the epithelium of the gut presents more hyperplasia, while the overexpression of jouvence prevents it. Molecularly, the mutant lack pseudouridylation on 18S and 28S-rRNA, a function rescued by targeted expression of jouvence in the gut. A transcriptomic analysis performed from the gut reveals that several genes are either up- or down-regulated, while restoring the mRNA level of two genes (ninaD or CG6296) rescue the longevity. Since snoRNAs are structurally and functionally well conserved throughout evolution, we identified putative jouvence orthologue in mammals including humans, suggesting that its function in longevity could be conserved. |
| 巻・号 | 11(1) |
| ページ | 987 |
| 公開日 | 2020-2-20 |
| DOI | 10.1038/s41467-020-14784-1 |
| PII | 10.1038/s41467-020-14784-1 |
| PMID | 32080190 |
| PMC | PMC7033134 |
| MeSH | Animals Animals, Genetically Modified Conserved Sequence Drosophila Proteins / genetics Drosophila melanogaster / genetics* Drosophila melanogaster / metabolism Enterocytes / metabolism Evolution, Molecular Female Gene Deletion Gene Expression Profiling Genome, Insect Humans Intestinal Mucosa / metabolism Longevity / genetics* Loss of Function Mutation Male Mice Nucleic Acid Conformation RNA, Messenger / genetics RNA, Messenger / metabolism RNA, Small Nucleolar / chemistry RNA, Small Nucleolar / genetics* RNA, Small Nucleolar / metabolism Receptors, Immunologic / genetics |
| IF | 12.121 |
| 引用数 | 0 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 18 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | 31783R-1 31783R-2 |