| RRC ID |
58619
|
| 著者 |
Isono T, Suzaki M.
|
| タイトル |
Analysis of the characteristics of chemotherapy-resistant renal cell carcinomas based on global transcriptional analysis of their tissues and cell lines.
|
| ジャーナル |
PLoS One
|
| Abstract |
Starvation-resistant renal cell carcinoma (RCC) cell lines are considered dormant-state cells that survive even under glucose starvation. The cellular biological and global transcriptional analysis using these cells identified potential markers of chemotherapy-resistant RCC and therapeutic agent candidates. Recently, we showed that ARL4C was a predictive biomarker for poor prognosis in patients with chemotherapy-resistant RCC by the global transcriptional analysis of patient primary tissues. The objective of this study was to identify the characteristics of chemotherapy-resistant RCC by the global transcriptional analysis of primary tissues of patients with RCC and RCC cell lines. The connective global transcriptional analysis showed that two starvation-resistant RCC cell lines, SW839 and KMRC-1, were strongly correlated to tissues of patients with chemotherapy-resistant RCC and showed high expressions of invasive- and proliferation-related genes. We found fibronectin (FN1) expression was a predictive biomarker in some patients with chemotherapy-resistant RCC, which especially correlated with two starvation-resistant RCC cell lines. These results indicate these cell lines emulate chemotherapy-resistant RCC and might be useful in the search for markers to predict poor prognosis and in the development of therapeutic agents and their index markers for chemotherapy-resistant RCCs.
|
| 巻・号 |
14(11)
|
| ページ |
e0225721
|
| 公開日 |
2019-11-27
|
| DOI |
10.1371/journal.pone.0225721
|
| PII |
PONE-D-19-15781
|
| PMID |
31774870
|
| PMC |
PMC6881023
|
| MeSH |
Antineoplastic Agents / pharmacology*
Biomarkers, Tumor / genetics*
Carcinoma, Renal Cell / drug therapy
Carcinoma, Renal Cell / genetics*
Carcinoma, Renal Cell / pathology
Drug Resistance, Neoplasm / genetics*
Fibronectins / genetics*
Gene Expression Profiling
Humans
Kidney Neoplasms / drug therapy
Kidney Neoplasms / genetics*
Kidney Neoplasms / pathology
Prognosis
Survival Rate
Transcriptome / drug effects*
Tumor Cells, Cultured
|
| IF |
2.74
|
| 引用数 |
0
|
| リソース情報 |
| ヒト・動物細胞 |
VMRC-RCW(RCB1963) |
