論文 - 詳細
| RRC ID | 58619 |
|---|---|
| 著者 | Isono T, Suzaki M. |
| タイトル | Analysis of the characteristics of chemotherapy-resistant renal cell carcinomas based on global transcriptional analysis of their tissues and cell lines. |
| ジャーナル | PLoS One |
| Abstract |
Starvation-resistant renal cell carcinoma (RCC) cell lines are considered dormant-state cells that survive even under glucose starvation. The cellular biological and global transcriptional analysis using these cells identified potential markers of chemotherapy-resistant RCC and therapeutic agent candidates. Recently, we showed that ARL4C was a predictive biomarker for poor prognosis in patients with chemotherapy-resistant RCC by the global transcriptional analysis of patient primary tissues. The objective of this study was to identify the characteristics of chemotherapy-resistant RCC by the global transcriptional analysis of primary tissues of patients with RCC and RCC cell lines. The connective global transcriptional analysis showed that two starvation-resistant RCC cell lines, SW839 and KMRC-1, were strongly correlated to tissues of patients with chemotherapy-resistant RCC and showed high expressions of invasive- and proliferation-related genes. We found fibronectin (FN1) expression was a predictive biomarker in some patients with chemotherapy-resistant RCC, which especially correlated with two starvation-resistant RCC cell lines. These results indicate these cell lines emulate chemotherapy-resistant RCC and might be useful in the search for markers to predict poor prognosis and in the development of therapeutic agents and their index markers for chemotherapy-resistant RCCs. |
| 巻・号 | 14(11) |
| ページ | e0225721 |
| 公開日 | 2019-11-27 |
| DOI | 10.1371/journal.pone.0225721 |
| PII | PONE-D-19-15781 |
| PMID | 31774870 |
| PMC | PMC6881023 |
| MeSH | Antineoplastic Agents / pharmacology* Biomarkers, Tumor / genetics* Carcinoma, Renal Cell / drug therapy Carcinoma, Renal Cell / genetics* Carcinoma, Renal Cell / pathology Drug Resistance, Neoplasm / genetics* Fibronectins / genetics* Gene Expression Profiling Humans Kidney Neoplasms / drug therapy Kidney Neoplasms / genetics* Kidney Neoplasms / pathology Prognosis Survival Rate Transcriptome / drug effects* Tumor Cells, Cultured |
| IF | 2.74 |
| 引用数 | 0 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | News |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | VMRC-RCW(RCB1963) |