Reference - Detail
| RRC ID | 59435 |
|---|---|
| Author | Amrit FRG, Naim N, Ratnappan R, Loose J, Mason C, Steenberge L, McClendon BT, Wang G, Driscoll M, Yanowitz JL, Ghazi A. |
| Title | The longevity-promoting factor, TCER-1, widely represses stress resistance and innate immunity. |
| Journal | Nat Commun |
| Abstract |
Stress resistance and longevity are positively correlated but emerging evidence indicates that they are physiologically distinct. Identifying factors with distinctive roles in these processes is challenging because pro-longevity genes often enhance stress resistance. We demonstrate that TCER-1, the Caenorhabditis elegans homolog of human transcription elongation and splicing factor, TCERG1, has opposite effects on lifespan and stress resistance. We previously showed that tcer-1 promotes longevity in germline-less C. elegans and reproductive fitness in wild-type animals. Surprisingly, tcer-1 mutants exhibit exceptional resistance against multiple stressors, including infection by human opportunistic pathogens, whereas, TCER-1 overexpression confers immuno-susceptibility. TCER-1 inhibits immunity only during fertile stages of life. Elevating its levels ameliorates the fertility loss caused by infection, suggesting that TCER-1 represses immunity to augment fecundity. TCER-1 acts through repression of PMK-1 as well as PMK-1-independent factors critical for innate immunity. Our data establish key roles for TCER-1 in coordinating immunity, longevity and fertility, and reveal mechanisms that distinguish length of life from functional aspects of aging. |
| Volume | 10(1) |
| Pages | 3042 |
| Published | 2019-7-17 |
| DOI | 10.1038/s41467-019-10759-z |
| PII | 10.1038/s41467-019-10759-z |
| PMID | 31316054 |
| PMC | PMC6637209 |
| MeSH | Aging / genetics Aging / immunology Animals Caenorhabditis elegans / physiology Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / immunology Caenorhabditis elegans Proteins / metabolism* Disease Susceptibility / immunology Fertility / genetics Gene Expression Regulation / physiology* Immunity, Innate / genetics* Longevity / genetics* Mitogen-Activated Protein Kinases / genetics Models, Animal Mutation Peptide Elongation Factors / genetics Peptide Elongation Factors / immunology Peptide Elongation Factors / metabolism* Stress, Physiological / genetics Stress, Physiological / immunology* |
| IF | 11.878 |
| Times Cited | 3 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 53 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm1452 |