論文 - 詳細
| RRC ID | 59570 |
|---|---|
| 著者 | Ou HL, Kim CS, Uszkoreit S, Wickström SA, Schumacher B. |
| タイトル | Somatic Niche Cells Regulate the CEP-1/p53-Mediated DNA Damage Response in Primordial Germ Cells. |
| ジャーナル | Dev Cell |
| Abstract |
Genome integrity in primordial germ cells (PGCs) is a prerequisite for fertility and species maintenance. In C. elegans, PGCs require global-genome nucleotide excision repair (GG-NER) to remove UV-induced DNA lesions. Failure to remove the lesions leads to the activation of the C. elegans p53, CEP-1, resulting in mitotic arrest of the PGCs. We show that the eIF4E2 translation initiation factor IFE-4 in somatic gonad precursor (SGP) niche cells regulates the CEP-1/p53-mediated DNA damage response (DDR) in PGCs. We determine that the IFE-4 translation target EGL-15/FGFR regulates the non-cell-autonomous DDR that is mediated via FGF-like signaling. Using hair follicle stem cells as a paradigm, we demonstrate that the eIF4E2-mediated niche cell regulation of the p53 response in stem cells is highly conserved in mammals. We thus reveal that the somatic niche regulates the CEP-1/p53-mediated DNA damage checkpoint in PGCs. Our data suggest that the somatic niche impacts the stability of heritable genomes. |
| 巻・号 | 50(2) |
| ページ | 167-183.e8 |
| 公開日 | 2019-7-22 |
| DOI | 10.1016/j.devcel.2019.06.012 |
| PII | S1534-5807(19)30530-1 |
| PMID | 31336098 |
| MeSH | Animals Apoptosis Caenorhabditis elegans Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Cells, Cultured DNA Damage* DNA Repair Eukaryotic Initiation Factors / genetics Eukaryotic Initiation Factors / metabolism* Female Fibroblast Growth Factors / metabolism* Germ Cells / metabolism Germ Cells / pathology* Male Mice Mice, Inbred C57BL Signal Transduction Tumor Suppressor Protein p53 / genetics Tumor Suppressor Protein p53 / metabolism* |
| IF | 9.19 |
| 引用数 | 1 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 33 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm684 tm3886 |