RRC ID 60087
Author Horstick EJ, Bayleyen Y, Burgess HA.
Title Molecular and cellular determinants of motor asymmetry in zebrafish.
Journal Nat Commun
Abstract Asymmetries in motor behavior, such as human hand preference, are observed throughout bilateria. However, neural substrates and developmental signaling pathways that impose underlying functional lateralization on a broadly symmetric nervous system are unknown. Here we report that in the absence of over-riding visual information, zebrafish larvae show intrinsic lateralized motor behavior that is mediated by a cluster of 60 posterior tuberculum (PT) neurons in the forebrain. PT neurons impose motor bias via a projection through the habenular commissure. Acquisition of left/right identity is disrupted by heterozygous mutations in mosaic eyes and mindbomb, genes that regulate Notch signaling. These results define the neuronal substrate for motor asymmetry in a vertebrate and support the idea that haploinsufficiency for genes in a core developmental pathway destabilizes left/right identity.
Volume 11(1)
Pages 1170
Published 2020-3-3
DOI 10.1038/s41467-020-14965-y
PII 10.1038/s41467-020-14965-y
PMID 32127541
PMC PMC7054361
MeSH Animals Animals, Genetically Modified Diencephalon / physiology Eye Proteins / genetics Habenula / physiology Larva / physiology Motor Activity / physiology* Mutation Neurons / physiology* Phototaxis Receptors, Notch / metabolism Reflex, Startle Ubiquitin-Protein Ligases / genetics Zebrafish / physiology* Zebrafish Proteins / genetics
IF 11.878
Times Cited 1
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