論文 - 詳細
| RRC ID | 60087 |
|---|---|
| 著者 | Horstick EJ, Bayleyen Y, Burgess HA. |
| タイトル | Molecular and cellular determinants of motor asymmetry in zebrafish. |
| ジャーナル | Nat Commun |
| Abstract |
Asymmetries in motor behavior, such as human hand preference, are observed throughout bilateria. However, neural substrates and developmental signaling pathways that impose underlying functional lateralization on a broadly symmetric nervous system are unknown. Here we report that in the absence of over-riding visual information, zebrafish larvae show intrinsic lateralized motor behavior that is mediated by a cluster of 60 posterior tuberculum (PT) neurons in the forebrain. PT neurons impose motor bias via a projection through the habenular commissure. Acquisition of left/right identity is disrupted by heterozygous mutations in mosaic eyes and mindbomb, genes that regulate Notch signaling. These results define the neuronal substrate for motor asymmetry in a vertebrate and support the idea that haploinsufficiency for genes in a core developmental pathway destabilizes left/right identity. |
| 巻・号 | 11(1) |
| ページ | 1170 |
| 公開日 | 2020-3-3 |
| DOI | 10.1038/s41467-020-14965-y |
| PII | 10.1038/s41467-020-14965-y |
| PMID | 32127541 |
| PMC | PMC7054361 |
| MeSH | Animals Animals, Genetically Modified Diencephalon / physiology Eye Proteins / genetics Habenula / physiology Larva / physiology Motor Activity / physiology* Mutation Neurons / physiology* Phototaxis Receptors, Notch / metabolism Reflex, Startle Ubiquitin-Protein Ligases / genetics Zebrafish / physiology* Zebrafish Proteins / genetics |
| IF | 11.878 |
| 引用数 | 1 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 52 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 52.0 |
| リソース情報 | |
| ゼブラフィッシュ | Tg(vglut2a:lRl-Gal4) |