論文 - 詳細
| RRC ID | 61886 |
|---|---|
| 著者 | Wan Z, Xu J, Huang Y, Zhai Y, Ma Z, Zhou B, Cao Z. |
| タイトル | Elevating bioavailable iron levels in mitochondria suppresses the defective phenotypes caused by PINK1 loss-of-function in Drosophila melanogaster. |
| ジャーナル | Biochem Biophys Res Commun |
| Abstract |
Parkinson's disease (PD) is the second most common progressive neurodegenerative disease, which is characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). Iron deposit was found in the SNpc of PD patients and animal models, however, the mechanisms involved in disturbed iron metabolism remain unknown. Identifying the relationship between iron metabolism and PD is important for finding new therapeutic strategies. In this study, we found that transgenic overexpression (OE) of Drosophila mitoferrin (dmfrn) or knockdown of Fer3HCH significantly mitigated the reduced mitochondrial aconitase activity, abnormal wing posture, flight deficits and mitochondrial morphology defects associated with PINK1 loss-of-function (LOF). Further work demonstrated that dmfrn OE or Fer3HCH knockdown significantly rescued the impaired mitochondrial respiration in PINK1 LOF flies, indicating that dmfrn or Fer3HCH may rescue PINK1 LOF phenotypes through elevating mitochondrial bioavailable iron levels to promote mitochondrial respiration. |
| 巻・号 | 532(2) |
| ページ | 285-291 |
| 公開日 | 2020-11-5 |
| DOI | 10.1016/j.bbrc.2020.08.002 |
| PII | S0006-291X(20)31547-3 |
| PMID | 32873392 |
| MeSH | Aconitate Hydratase / metabolism Animals Animals, Genetically Modified Basic Helix-Loop-Helix Transcription Factors / genetics Biological Availability Drosophila Proteins / genetics* Drosophila Proteins / metabolism Drosophila melanogaster / genetics Gene Expression Iron / metabolism* Loss of Function Mutation Mitochondria / drug effects Mitochondria / genetics Mitochondria / metabolism* Nerve Tissue Proteins / genetics Protein Serine-Threonine Kinases / genetics* Protein Serine-Threonine Kinases / metabolism Rotenone / toxicity Wings, Animal / physiopathology |
| IF | 2.985 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 6 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | 4349R-3 4963R-2 |