論文 - 詳細
| RRC ID | 61965 |
|---|---|
| 著者 | Yahara Y, Takemori H, Okada M, Kosai A, Yamashita A, Kobayashi T, Fujita K, Itoh Y, Nakamura M, Fuchino H, Kawahara N, Fukui N, Watanabe A, Kimura T, Tsumaki N. |
| タイトル | Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3. |
| ジャーナル | Nat Commun |
| Abstract |
Osteoarthritis is a common debilitating joint disorder. Risk factors for osteoarthritis include age, which is associated with thinning of articular cartilage. Here we generate chondrocyte-specific salt-inducible kinase 3 (Sik3) conditional knockout mice that are resistant to osteoarthritis with thickened articular cartilage owing to a larger chondrocyte population. We also identify an edible Pteridium aquilinum compound, pterosin B, as a Sik3 pathway inhibitor. We show that either Sik3 deletion or intraarticular injection of mice with pterosin B inhibits chondrocyte hypertrophy and protects cartilage from osteoarthritis. Collectively, our results suggest Sik3 regulates the homeostasis of articular cartilage and is a target for the treatment of osteoarthritis, with pterosin B as a candidate therapeutic. |
| 巻・号 | 7 |
| ページ | 10959 |
| 公開日 | 2016-3-24 |
| DOI | 10.1038/ncomms10959 |
| PII | ncomms10959 |
| PMID | 27009967 |
| PMC | PMC4820810 |
| MeSH | Aged Aged, 80 and over Animals Antineoplastic Agents / pharmacology* Blotting, Western Cartilage, Articular / drug effects Cartilage, Articular / metabolism* Cartilage, Articular / pathology Cells, Cultured Chondrocytes / drug effects Chondrocytes / metabolism* Chondrocytes / pathology Female Humans Hypertrophy Immunoblotting Indans / pharmacology* Male Mice Mice, Knockout Middle Aged Organ Size Osteoarthritis, Knee / metabolism* Osteoarthritis, Knee / pathology Phosphorylation Protein Kinases / metabolism* Protein Serine-Threonine Kinases / drug effects Protein Serine-Threonine Kinases / genetics* Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction |
| IF | 12.121 |
| リソース情報 | |
| ヒト・動物細胞 | ATDC5(RCB0565) |