論文 - 詳細
RRC ID | 6312 |
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著者 | Amin NM, Lim SE, Shi H, Chan TL, Liu J. |
タイトル | A conserved Six-Eya cassette acts downstream of Wnt signaling to direct non-myogenic versus myogenic fates in the C. elegans postembryonic mesoderm. |
ジャーナル | Dev Biol |
Abstract |
The subdivision of mesodermal cells into muscle and non-muscle cells is crucial to animal development. In the C. elegans postembryonic mesoderm, this subdivision is a result of an asymmetric cell division that leads to the formation of striated body wall muscles and non-muscle coelomocytes. Here we report that the Six homeodomain protein CEH-34 and its cofactor Eyes Absent, EYA-1, function synergistically to promote the non-muscle fate in cells also competent to form muscles. We further show that the asymmetric expression of ceh-34 and eya-1 is regulated by a combination of 1) mesodermal intrinsic factors MAB-5, HLH-1 and FOZI-1, 2) differential POP-1 (TCF/LEF) transcriptional activity along the anterior-posterior axis, and 3) coelomocyte competence factor(s). These factors are conserved in both vertebrates and invertebrates, suggesting a conserved paradigm for mesoderm development in metazoans. |
巻・号 | 331(2) |
ページ | 350-60 |
公開日 | 2009-7-15 |
DOI | 10.1016/j.ydbio.2009.05.538 |
PII | S0012-1606(09)00303-0 |
PMID | 19427847 |
PMC | PMC2703692 |
MeSH | Animals Animals, Genetically Modified Antigens, Differentiation / metabolism Caenorhabditis elegans / embryology Caenorhabditis elegans / growth & development Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / metabolism* Gene Expression Regulation, Developmental Homeodomain Proteins / metabolism* Intracellular Signaling Peptides and Proteins / metabolism* Mesoderm / growth & development Mesoderm / physiology* Muscle Development Muscles / cytology Muscles / embryology Nuclear Proteins / metabolism* Protein Tyrosine Phosphatases / metabolism* Signal Transduction / physiology Transcription Factors / metabolism* Wnt Proteins / metabolism* |
IF | 2.896 |
引用数 | 19 |
WOS 分野 | DEVELOPMENTAL BIOLOGY |
リソース情報 | |
線虫 | tm3330 tm3733 |