論文 - 詳細
| RRC ID | 6335 |
|---|---|
| 著者 | Yamamoto M, Morita R, Mizoguchi T, Matsuo H, Isoda M, Ishitani T, Chitnis AB, Matsumoto K, Crump JG, Hozumi K, Yonemura S, Kawakami K, Itoh M. |
| タイトル | Mib-Jag1-Notch signalling regulates patterning and structural roles of the notochord by controlling cell-fate decisions. |
| ジャーナル | Development |
| Abstract |
In the developing embryo, cell-cell signalling is necessary for tissue patterning and structural organization. During midline development, the notochord plays roles in the patterning of its surrounding tissues while forming the axial structure; however, how these patterning and structural roles are coordinated remains elusive. Here, we identify a mechanism by which Notch signalling regulates the patterning activities and structural integrity of the notochord. We found that Mind bomb (Mib) ubiquitylates Jagged 1 (Jag1) and is essential in the signal-emitting cells for Jag1 to activate Notch signalling. In zebrafish, loss- and gain-of-function analyses showed that Mib-Jag1-Notch signalling favours the development of non-vacuolated cells at the expense of vacuolated cells in the notochord. This leads to changes in the peri-notochordal basement membrane formation and patterning surrounding the muscle pioneer cells. These data reveal a previously unrecognized mechanism regulating the patterning and structural roles of the notochord by Mib-Jag1-Notch signalling-mediated cell-fate determination. |
| 巻・号 | 137(15) |
| ページ | 2527-37 |
| 公開日 | 2010-8-1 |
| DOI | 10.1242/dev.051011 |
| PII | dev.051011 |
| PMID | 20573700 |
| PMC | PMC2927672 |
| MeSH | 3T3 Cells Animals Body Patterning* COS Cells Calcium-Binding Proteins / metabolism* Cell Lineage* Chlorocebus aethiops Endocytosis Gene Expression Regulation, Developmental* Intercellular Signaling Peptides and Proteins / metabolism* Jagged-1 Protein Membrane Proteins / metabolism* Mice Models, Biological Notochord / physiology* Receptors, Notch / metabolism* Serrate-Jagged Proteins Two-Hybrid System Techniques Ubiquitin / metabolism Ubiquitin-Protein Ligases / metabolism* Zebrafish Zebrafish Proteins / metabolism* |
| IF | 5.611 |
| 引用数 | 54 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 16 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 3.0 |
| リソース情報 | |
| ゼブラフィッシュ | SAGFF(LF)214A Tg(UAS:GFP) |