論文 - 詳細
| RRC ID | 6344 |
|---|---|
| 著者 | Cohen M, Reale V, Olofsson B, Knights A, Evans P, de Bono M. |
| タイトル | Coordinated regulation of foraging and metabolism in C. elegans by RFamide neuropeptide signaling. |
| ジャーナル | Cell Metab |
| Abstract |
Animals modify food-seeking behavior and metabolism according to perceived food availability. Here we show that, in the roundworm C. elegans, release of neuropeptides from interneurons that are directly postsynaptic to olfactory, gustatory, and thermosensory neurons coordinately regulates behavior and metabolism. Animals lacking these neuropeptides, encoded by the flp-18 gene, are defective in chemosensation and foraging, accumulate excess fat, and exhibit reduced oxygen consumption. Two G protein-coupled receptors of the NPY/RFamide family, NPR-4 and NPR-5, are activated by FLP-18 peptides in vitro and exhibit mutant phenotypes that recapitulate those of flp-18 mutants. Our data suggest that sensory input can coordinately regulate behavior and metabolism via NPY/RFamide-like receptors. They suggest that peptidergic feedback from interneurons regulates sensory neuron activity, and that at least some of this communication occurs extrasynaptically. Extrasynaptic neuropeptide signaling may greatly increase the computational capacity of neural circuits. |
| 巻・号 | 9(4) |
| ページ | 375-85 |
| 公開日 | 2009-4-1 |
| DOI | 10.1016/j.cmet.2009.02.003 |
| PII | S1550-4131(09)00041-2 |
| PMID | 19356718 |
| MeSH | Animals Caenorhabditis elegans / cytology Caenorhabditis elegans / growth & development Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / metabolism Feeding Behavior* Interneurons / cytology Interneurons / metabolism Intestinal Mucosa / metabolism Intestines / cytology Lipid Metabolism Models, Biological Mutation / genetics Neuropeptide Y / metabolism Neuropeptides / metabolism* Odorants Organ Specificity Peptides / metabolism Phenotype Receptors, Cell Surface / metabolism Signal Transduction* Xenopus |
| IF | 21.567 |
| 引用数 | 56 |
| WOS 分野 | ENDOCRINOLOGY & METABOLISM CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| 線虫 | tm1583 tm1782 tm1497 tm1553 tm1498 tm1504 |