論文 - 詳細
| RRC ID | 6383 |
|---|---|
| 著者 | Karakuzu O, Wang DP, Cameron S. |
| タイトル | MIG-32 and SPAT-3A are PRC1 homologs that control neuronal migration in Caenorhabditis elegans. |
| ジャーナル | Development |
| Abstract |
The Polycomb repression complex 2 (PRC2) methylates histone H3 lysine 27 at target genes to modify gene expression, and this mark is recognized by PRC1, which ubiquitylates histone H2A. In Caenorhabditis elegans, a complex of the MES-2, MES-3 and MES-6 proteins is functionally analogous to the PRC2 complex, but the functional analog of PRC1, and indeed whether C. elegans has such a complex, has been unclear. We describe here that MIG-32 and SPAT-3A are functional analogs of PRC1 in C. elegans, where they are required for neuronal migrations and during vulval development. mig-32 and spat-3 mutants are defective in H2A ubiquitylation, and have nervous system defects that partially overlap with those of mes mutants. However, unlike the mes mutants, mig-32 and spat-3 mutants are fertile, suggesting that PRC1 function is not absolutely required in the germline for essential functions of PRC2. |
| 巻・号 | 136(6) |
| ページ | 943-53 |
| 公開日 | 2009-3-1 |
| DOI | 10.1242/dev.029363 |
| PII | dev.029363 |
| PMID | 19211678 |
| PMC | PMC2727560 |
| MeSH | Amino Acid Sequence Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / growth & development Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / chemistry Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Carrier Proteins / genetics Carrier Proteins / metabolism* Cell Movement* Cell Nucleus / metabolism Gene Expression Regulation, Developmental Histones / metabolism Humans Intracellular Signaling Peptides and Proteins Male Molecular Sequence Data Mutation / genetics Neurons / cytology* Neurons / metabolism* Nuclear Proteins / genetics Nuclear Proteins / metabolism Polycomb-Group Proteins Repressor Proteins / genetics Repressor Proteins / metabolism Sequence Alignment Sequence Homology, Amino Acid Ubiquitination |
| IF | 5.611 |
| 引用数 | 14 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY |
| リソース情報 | |
| 線虫 | tm1807 tm1684 |