論文 - 詳細
| RRC ID | 64562 |
|---|---|
| 著者 | Horspool AM, Chang HC. |
| タイトル | Superoxide dismutase SOD-1 modulates C. elegans pathogen avoidance behavior. |
| ジャーナル | Sci Rep |
| Abstract |
The C. elegans nervous system mediates protective physiological and behavioral responses amid infection. However, it remains largely unknown how the nervous system responds to reactive oxygen species (ROS) activated by pathogenic microbes during infection. Here, we show superoxide dismutase-1 (SOD-1), an enzyme that converts superoxide into less toxic hydrogen peroxide and oxygen, functions in the gustatory neuron ASER to mediate C. elegans pathogen avoidance response. When C. elegans first encounters pathogenic bacteria P. aeruginosa, SOD-1 is induced in the ASER neuron. After prolonged P. aeruginosa exposure, ASER-specific SOD-1 expression is diminished. In turn, C. elegans starts to vacate the pathogenic bacteria lawn. Genetic knockdown experiments reveal that pathogen-induced ROS activate sod-1 dependent behavioral response non cell-autonomously. We postulate that the delayed aversive response to detrimental microbes may provide survival benefits by allowing C. elegans to temporarily utilize food that is tainted with pathogens as an additional energy source. Our data offer a mechanistic insight into how the nervous system mediates food-seeking behavior amid oxidative stress and suggest that the internal state of redox homeostasis could underlie the behavioral response to harmful microbial species. |
| 巻・号 | 7 |
| ページ | 45128 |
| 公開日 | 2017-3-21 |
| DOI | 10.1038/srep45128 |
| PII | srep45128 |
| PMID | 28322326 |
| PMC | PMC5359715 |
| MeSH | Animals Avoidance Learning* Behavior, Animal Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Cilia / metabolism Gene Expression Host-Pathogen Interactions* Mutation Nervous System / metabolism Neurons / metabolism Organ Specificity Oxidative Stress Pseudomonas aeruginosa Reactive Oxygen Species / metabolism Superoxide Dismutase-1 / genetics* Superoxide Dismutase-1 / metabolism* |
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