RRC ID 67822
著者 Nakagoshi H, Shirai T, Nabeshima Y, Matsuzaki F.
タイトル Refinement of wingless expression by a wingless- and notch-responsive homeodomain protein, defective proventriculus.
ジャーナル Dev Biol
Abstract Pattern formation during animal development is often induced by extracellular signaling molecules, known as morphogens, which are secreted from localized sources. During wing development in Drosophila, Wingless (Wg) is activated by Notch signaling along the dorsal-ventral boundary of the wing imaginal disc and acts as a morphogen to organize gene expression and cell growth. Expression of wg is restricted to a narrow stripe by Wg itself, repressing its own expression in adjacent cells. This refinement of wg expression is essential for specification of the wing margin. Here, we show that a homeodomain protein, Defective proventriculus (Dve), mediates the refinement of wg expression in both the wing disc and embryonic proventriculus, where dve expression requires Wg signaling. Our results provide evidence for a feedback mechanism that establishes the wg-expressing domain through the action of a Wg-induced gene product.
巻・号 249(1)
ページ 44-56
公開日 2002-9-1
DOI 10.1006/dbio.2002.0746
PII S0012160602907463
PMID 12217317
MeSH Animals Body Patterning / physiology Digestive System / embryology* Digestive System / metabolism Drosophila / embryology Drosophila / genetics* Drosophila Proteins / genetics Drosophila Proteins / metabolism Embryo, Nonmammalian Gene Expression Regulation, Developmental Homeodomain Proteins / genetics* Homeodomain Proteins / metabolism Membrane Proteins / genetics Membrane Proteins / metabolism* Mosaicism Mutation Proto-Oncogene Proteins / genetics Proto-Oncogene Proteins / metabolism* Receptors, Notch Signal Transduction Wings, Animal / embryology Wings, Animal / metabolism Wnt1 Protein
IF 2.896
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