論文 - 詳細
| RRC ID | 67946 |
|---|---|
| 著者 | Pan X, O'Connor MB. |
| タイトル | Coordination among multiple receptor tyrosine kinase signals controls Drosophila developmental timing and body size. |
| ジャーナル | Cell Rep |
| Abstract |
In holometabolous insects, metamorphic timing and body size are controlled by a neuroendocrine axis composed of the ecdysone-producing prothoracic gland (PG) and its presynaptic neurons (PGNs) producing PTTH. Although PTTH/Torso signaling is considered the primary mediator of metamorphic timing, recent studies indicate that other unidentified PGN-derived factors also affect timing. Here, we demonstrate that the receptor tyrosine kinases anaplastic lymphoma kinase (Alk) and PDGF and VEGF receptor-related (Pvr), function in coordination with PTTH/Torso signaling to regulate pupariation timing and body size. Both Alk and Pvr trigger Ras/Erk signaling in the PG to upregulate expression of ecdysone biosynthetic enzymes, while Alk also suppresses autophagy by activating phosphatidylinositol 3-kinase (PI3K)/Akt. The Alk ligand Jelly belly (Jeb) is produced by the PGNs and serves as a second PGN-derived tropic factor, while Pvr activation mainly relies on autocrine signaling by PG-derived Pvf2 and Pvf3. These findings illustrate that a combination of juxtacrine and autocrine signaling regulates metamorphic timing, the defining event of holometabolous development. |
| 巻・号 | 36(9) |
| ページ | 109644 |
| 公開日 | 2021-8-31 |
| DOI | 10.1016/j.celrep.2021.109644 |
| PII | S2211-1247(21)01087-1 |
| PMID | 34469735 |
| PMC | PMC8428980 |
| MeSH | Animals Animals, Genetically Modified Autocrine Communication Body Size Drosophila Proteins / genetics Drosophila Proteins / metabolism* Drosophila melanogaster / embryology Drosophila melanogaster / enzymology* Drosophila melanogaster / genetics Ecdysone / metabolism Endocrine Glands / embryology Endocrine Glands / enzymology* ErbB Receptors / genetics ErbB Receptors / metabolism Extracellular Signal-Regulated MAP Kinases / genetics Extracellular Signal-Regulated MAP Kinases / metabolism Gene Expression Regulation, Developmental IMP Dehydrogenase / genetics IMP Dehydrogenase / metabolism Janus Kinases / genetics Janus Kinases / metabolism Metamorphosis, Biological* Mutation Receptor Protein-Tyrosine Kinases / genetics Receptor Protein-Tyrosine Kinases / metabolism* Receptors, Invertebrate Peptide / genetics Receptors, Invertebrate Peptide / metabolism STAT Transcription Factors / genetics STAT Transcription Factors / metabolism Signal Transduction Time Factors Transcription Factors / genetics Transcription Factors / metabolism Vascular Endothelial Growth Factors / genetics Vascular Endothelial Growth Factors / metabolism |
| IF | 8.109 |
| リソース情報 | |
| ショウジョウバエ | 13780R-2 13781R-1 |