論文 - 詳細
| RRC ID | 70821 |
|---|---|
| 著者 | Ryan SM, Almassey M, Burch AM, Ngo G, Martin JM, Myers D, Compton D, Archie S, Cross M, Naeger L, Salzman A, Virola-Iarussi A, Barbee SA, Mortimer NT, Sanyal S, Vrailas-Mortimer AD. |
| タイトル | Drosophila p38 MAPK interacts with BAG-3/starvin to regulate age-dependent protein homeostasis. |
| ジャーナル | Aging Cell |
| Abstract |
As organisms age, they often accumulate protein aggregates that are thought to be toxic, potentially leading to age-related diseases. This accumulation of protein aggregates is partially attributed to a failure to maintain protein homeostasis. A variety of genetic factors have been linked to longevity, but how these factors also contribute to protein homeostasis is not completely understood. In order to understand the relationship between aging and protein aggregation, we tested how a gene that regulates lifespan and age-dependent locomotor behaviors, p38 MAPK (p38Kb), influences protein homeostasis as an organism ages. We find that p38Kb regulates age-dependent protein aggregation through an interaction with starvin, a regulator of muscle protein homeostasis. Furthermore, we have identified Lamin as an age-dependent target of p38Kb and starvin. |
| 巻・号 | 20(11) |
| ページ | e13481 |
| 公開日 | 2021-11-1 |
| DOI | 10.1111/acel.13481 |
| PMID | 34674371 |
| PMC | PMC8590102 |
| MeSH | Aging / genetics Aging / metabolism* Animals Animals, Genetically Modified Drosophila Proteins / genetics Drosophila Proteins / metabolism* Drosophila melanogaster / genetics Drosophila melanogaster / metabolism* Female Gene Deletion Lamins / metabolism Locomotion / genetics Longevity / genetics* MAP Kinase Signaling System / genetics* Macroautophagy / genetics Muscles / metabolism Oxidative Stress / genetics Phenotype Proteolysis Proteostasis / genetics* RNA Interference p38 Mitogen-Activated Protein Kinases / genetics p38 Mitogen-Activated Protein Kinases / metabolism* |
| IF | 7.238 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 13 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#115622 DGRC#115336 |