RRC ID 70884
Author Bühler A, Carl M.
Title Zebrafish Tools for Deciphering Habenular Network-Linked Mental Disorders.
Journal Biomolecules
Abstract The prevalence of patients suffering from mental disorders is substantially increasing in recent years and represents a major burden to society. The underlying causes and neuronal circuits affected are complex and difficult to unravel. Frequent disorders such as depression, schizophrenia, autism, and bipolar disorder share links to the habenular neural circuit. This conserved neurotransmitter system relays cognitive information between different brain areas steering behaviors ranging from fear and anxiety to reward, sleep, and social behaviors. Advances in the field using the zebrafish model organism have uncovered major genetic mechanisms underlying the formation of the habenular neural circuit. Some of the identified genes involved in regulating Wnt/beta-catenin signaling have previously been suggested as risk genes of human mental disorders. Hence, these studies on habenular genetics contribute to a better understanding of brain diseases. We are here summarizing how the gained knowledge on the mechanisms underlying habenular neural circuit development can be used to introduce defined manipulations into the system to study the functional behavioral consequences. We further give an overview of existing behavior assays to address phenotypes related to mental disorders and critically discuss the power but also the limits of the zebrafish model for identifying suitable targets to develop therapies.
Volume 11(2)
Published 2021-2-20
DOI 10.3390/biom11020324
PII biom11020324
PMID 33672636
PMC PMC7924194
MeSH Animals Anxiety Axons / metabolism Behavior, Animal Depression / drug therapy Depression / metabolism Depression / physiopathology Disease Models, Animal Habenula / metabolism Habenula / physiology* Mental Disorders / genetics* Mental Disorders / metabolism Mutation Nerve Net Neurogenesis Neurons / metabolism Neurotransmitter Agents Phenotype Social Behavior Wnt Proteins / metabolism Wnt Signaling Pathway Zebrafish / genetics* Zebrafish / physiology Zebrafish Proteins / genetics
IF 4.082
Zebrafish Tg(narp:GALVP16) Tg(UAS:TeNT) Tg(brn3a-hsp70:GFP) Tg(gpr151:GAL4VP16) Tg(brn3a-hsp70:GFP-Cre) Tg(UAS:loxP-DsRed-loxP-GFP-TeNT)