論文 - 詳細
| RRC ID | 82120 |
|---|---|
| 著者 | Suda K, Moriyama Y, Razali N, Chiu Y, Masukagami Y, Nishimura K, Barbee H, Takase H, Sugiyama S, Yamazaki Y, Sato Y, Higashiyama T, Johmura Y, Nakanishi M, Kono K. |
| タイトル | Plasma membrane damage limits replicative lifespan in yeast and induces premature senescence in human fibroblasts. |
| ジャーナル | Nat Aging |
| Abstract |
Plasma membrane damage (PMD) occurs in all cell types due to environmental perturbation and cell-autonomous activities. However, cellular outcomes of PMD remain largely unknown except for recovery or death. In this study, using budding yeast and normal human fibroblasts, we found that cellular senescence-stable cell cycle arrest contributing to organismal aging-is the long-term outcome of PMD. Our genetic screening using budding yeast unexpectedly identified a close genetic association between PMD response and replicative lifespan regulations. Furthermore, PMD limits replicative lifespan in budding yeast; upregulation of membrane repair factors ESCRT-III (SNF7) and AAA-ATPase (VPS4) extends it. In normal human fibroblasts, PMD induces premature senescence via the Ca2+-p53 axis but not the major senescence pathway, DNA damage response pathway. Transient upregulation of ESCRT-III (CHMP4B) suppressed PMD-dependent senescence. Together with mRNA sequencing results, our study highlights an underappreciated but ubiquitous senescent cell subtype: PMD-dependent senescent cells. |
| 巻・号 | 4(3) |
| ページ | 319-335 |
| 公開日 | 2024-3-1 |
| DOI | 10.1038/s43587-024-00575-6 |
| PII | 10.1038/s43587-024-00575-6 |
| PMID | 38388781 |
| PMC | PMC10950784 |
| MeSH | Adenosine Triphosphatases / metabolism Cell Membrane / metabolism Cellular Senescence / genetics Endosomal Sorting Complexes Required for Transport / genetics Fibroblasts Humans Longevity Saccharomyces cerevisiae* / genetics Saccharomyces cerevisiae Proteins* / metabolism Tumor Suppressor Protein p53 / genetics |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 451 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | HeLa(RCB0007) WI-38(RCB0702) |