Reference - Detail
| RRC ID | 86913 |
|---|---|
| Author | Restrepo LJ, Graslie JK, Fortier TM, Baehrecke EH. |
| Title | The conserved outer mitochondrial membrane protein Mtch regulates mitophagy during Drosophila intestinal development. |
| Journal | PLoS Biol |
| Abstract |
The clearance of mitochondria by autophagy (mitophagy) is important for cell health. Mutations in genes that are required for mitophagy, including Vps13D, PINK1, and Parkin, are associated with movement disorders, but gaps exist in our understanding of how Vps13D regulates mitophagy. Here, we identify Mtch (MTCH2 in humans) as a regulator of mitophagy based on a relationship with Vps13D during developmentally programmed mitophagy in Drosophila intestine enterocyte cells. Similar to Vps13D mutant cells, Mtch mutant cells fail to clear mitochondria and possess elevated markers of autophagy. Genetic and molecular experiments reveal that Mtch and Vps13D function in a mitophagy pathway with PINK1, Parkin, and the mitophagy receptor BNIP3. Unlike Vps13D and Parkin mutant cells, Mtch is required for proper expression of the tail-anchored protein BNIP3. Thus, the tail-anchored protein insertase function of Mtch/MTCH2 likely explains how these proteins possess multiple cell context-specific functions. |
| Volume | 24(1) |
| Pages | e3003616 |
| Published | 2026-1-1 |
| DOI | 10.1371/journal.pbio.3003616 |
| PII | PBIOLOGY-D-25-02930 |
| PMID | 41576035 |
| PMC | PMC12829841 |
| MeSH | Animals Drosophila Proteins* / genetics Drosophila Proteins* / metabolism Drosophila melanogaster* / genetics Drosophila melanogaster* / growth & development Drosophila melanogaster* / metabolism Enterocytes / metabolism Humans Intestines* / embryology Intestines* / growth & development Membrane Proteins / genetics Membrane Proteins / metabolism Mitochondria / metabolism Mitochondrial Membranes / metabolism Mitochondrial Proteins* / genetics Mitochondrial Proteins* / metabolism Mitophagy* / genetics Mitophagy* / physiology Mutation PTEN-Induced Putative Kinase Protein Serine-Threonine Kinases / genetics Protein Serine-Threonine Kinases / metabolism Ubiquitin-Protein Ligases / genetics Ubiquitin-Protein Ligases / metabolism |
| IF | 7.076 |
| Resource | |
| Drosophila | |