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  • Search Condition : Filter (MeSH = Guanine Nucleotide Exchange Factors)
Species Resource Title
Human and Animal Cells OS-RC-2(RCB0735) The significance of Ras guanine nucleotide exchange factor, son of sevenless protein, in renal cell carcinoma cell lines.
Human and Animal Cells HOUA-I(RCB0659) Tumor-derived ARHGAP35 mutations enhance the Gα13-Rho signaling axis in human endometrial cancer.
DNA material EGFP-hEFA6A (RDB20108) , EGFP-hEFA6B (RDB20109) , EGFP-hEFA6C (RDB20110) EFA6 activates Arf6 and participates in its targeting to the Flemming body during cytokinesis.
DNA material pEF-T7-HPS4 (RDB17366) , pEF-T7-GST-RBD32/38 (RDB17371) RUTBC1 Functions as a GTPase-activating Protein for Rab32/38 and Regulates Melanogenic Enzyme Trafficking in Melanocytes.
Drosophila Control of basal autophagy rate by vacuolar peduncle.
DNA material pYO12 (RDB08771) , pYOSAR (RDB08772) , pANY4-2 (RDB08773) , pYS3 (RDB08774) , pYO112KS-1 (RDB08775) , pYS1-6 (RDB08776) , pYS2-2B (RDB08777). Identification of SEC12, SED4, truncated SEC16, and EKS1/HRD3 as multicopy suppressors of ts mutants of Sar1 GTPase.
C.elegans tm2342 , tm2375 AGS-3 alters Caenorhabditis elegans behavior after food deprivation via RIC-8 activation of the neural G protein G αo.
Human and Animal Cells OS-RC-2(RCB0735) Identification of novel targets for antiangiogenic therapy by comparing the gene expressions of tumor and normal endothelial cells.
Human and Animal Cells 293T(RCB2202) DOCK7 is a critical regulator of the RAGE-Cdc42 signaling axis that induces formation of dendritic pseudopodia in human cancer cells.
Human and Animal Cells WI-38 Sphingosine 1-phosphate induces alpha-smooth muscle actin expression in lung fibroblasts via Rho-kinase.
DNA material pAM5-2 (RDB08778) , pAM6-2 (RDB08779) , pAM4-1 (RDB08780) , pAM8-2 (RDB08781) , pAM2-326 (RDB08782) , pAM1-5 (RDB08783) , pAM1-2 (RDB08784) , pAM8-1 (K38A) (RDB08785) , pAM13-2 (RDB08786) , pAM13-3 (RDB08787). The inactive form of a yeast casein kinase I suppresses the secretory defect of the sec12 mutant. Implication of negative regulation by the Hrr25 kinase in the vesicle budding from the endoplasmic reticulum.
Yeast FY7520 , FY7251 , FY7132 , FY6767 , FY7643 , FY6873 , FY7085 Coordinated regulation by two VPS9 domain-containing guanine nucleotide exchange factors in small GTPase Rab5 signaling pathways in fission yeast.
DNA material 316-GFP-SEC12 (RDB08651) , 316-M71W71 (RDB08633) , 316-M71WWS (RDB08630) , 316-MW71WS (RDB08631) , 316-MW71WS/1L (RDB08638) , 316-MW71WS/2L (RDB08639) , 316-MW71WS/2L delta LV (RDB08642) , 316-MW71WS/3L (RDB08640) , 316-MW71WS/4L (RDB08641) , 316-MW71WS/delta L (RDB08637) , ... Rer1p, a retrieval receptor for ER membrane proteins, recognizes transmembrane domains in multiple modes.
DNA material rer2::LEU2 (RDB08836) , pRER206 SRT1disruption (RDB08837) , pY1 (RDB08835) , pR7 (RDB08838) , pR7HA (RDB08839) , pR7HA-4 (RDB08840) , pR7HA-2 (RDB08841) The yeast RER2 gene, identified by endoplasmic reticulum protein localization mutations, encodes cis-prenyltransferase, a key enzyme in dolichol synthesis.
DNA material pSHF2-1 (RDB08870) , pSHY6-3 (RDB08871) , pSHF9-4 (RDB08872) , pSHF9-4 delta Sal (RDB08873) , pSHF11-1 (RDB08874) Identification of a gene required for membrane protein retention in the early secretory pathway.
DNA material pSHY13-2 (RDB08867) , pSHY15-1 (RDB08869) , pSHY14-5 (RDB08868) Inhibition of endoplasmic reticulum (ER)-to-Golgi transport induces relocalization of binding protein (BiP) within the ER to form the BiP bodies.
DNA material pYO324/RER1-3HA (RDB085969 , pYO324/RER1-3HA Y152L (RDB08597) , pSK/rer1::LEU2 (RDB08649) , pRS314/RERI-3HA (RDB08654) Membrane protein retrieval from the Golgi apparatus to the endoplasmic reticulum (ER): characterization of the RER1 gene product as a component involved in ER localization of Sec12p.
DNA material pMS2-3 (pSSS-1) (RDB08842) , pDDD-2 (pSD1-2 , pMD2-6) (RDB08843) , pDSS-2 (pSD4-2) (RDB08844) , pDDS-2 (pSD3-2) (RDB08845) , pSDS-2 (pSD2-2) (RDB08846) , pSSD-2 (pSD7-2) (RDB08847) , pDSD-2 (pSD5-2) (RDB08848) , pSDD-2 (pSD6-2) (RDB08849) , pDSDm F-A (RDB08850) , ... Endoplasmic reticulum localization of Sec12p is achieved by two mechanisms: Rer1p-dependent retrieval that requires the transmembrane domain and Rer1p-independent retention that involves the cytoplasmic domain.
DNA material pSKY5-RER1-0 (RDB08615) , pSKY5-RER1-5 (RDB08616) , pSKY5-RER1-10 (RDB08617) , pSKY5-RER1-15 (RDB08618) , pSKY5-RER1-20 (RDB08619) , pSKY5-RER1-25 (RDB08620) , pSKY5-RER1 G179A (RDB08621) , pSKY5-RER1-K180S (RDB08622) , pSKY5-RER1-K181S (RDB08623) , pSKY5-RER1-K182S (RDB08624) , ... Rer1p, a retrieval receptor for endoplasmic reticulum membrane proteins, is dynamically localized to the Golgi apparatus by coatomer.
DNA material pKSY193 (RDB08689) , pKSY197 (RDB08690) , pKSY198 (RDB08691) , pET21a-SED5 (RDB08692) , pKSE165 (RDB08708) , pKSE168 (RDB08709) , pKSE174 (RDB08710) , pKSE176 (RDB08711) , pKSE188 (RDB08712) , pKSE203 (RDB08713) Dissection of COPII subunit-cargo assembly and disassembly kinetics during Sar1p-GTP hydrolysis.