論文 - 詳細
| RRC ID | 21893 |
|---|---|
| 著者 | Agrawal N, Venkiteswaran G, Sadaf S, Padmanabhan N, Banerjee S, Hasan G. |
| タイトル | Inositol 1,4,5-trisphosphate receptor and dSTIM function in Drosophila insulin-producing neurons regulates systemic intracellular calcium homeostasis and flight. |
| ジャーナル | J Neurosci |
| Abstract |
Calcium (Ca(2+)) signaling is known to regulate the development, maintenance and modulation of activity in neuronal circuits that underlie organismal behavior. In Drosophila, intracellular Ca(2+) signaling by the inositol 1,4,5-trisphosphate receptor and the store-operated channel (dOrai) regulates the formation and function of neuronal circuits that control flight. Here, we show that restoring InsP(3)R activity in insulin-producing neurons of flightless InsP(3)R mutants (itpr) during pupal development can rescue systemic flight ability. Expression of the store operated Ca(2+) entry (SOCE) regulator dSTIM in insulin-producing neurons also suppresses compromised flight ability of InsP(3)R mutants suggesting that SOCE can compensate for impaired InsP(3)R function. Despite restricted expression of wild-type InsP(3)R and dSTIM in insulin-producing neurons, a global restoration of SOCE and store Ca(2+) is observed in primary neuronal cultures from the itpr mutant. These results suggest that restoring InsP(3)R-mediated Ca(2+) release and SOCE in a limited subset of neuromodulatory cells can influence systemic behaviors such as flight by regulating intracellular Ca(2+) homeostasis in a large population of neurons through a non-cell-autonomous mechanism. |
| 巻・号 | 30(4) |
| ページ | 1301-13 |
| 公開日 | 2010-1-27 |
| DOI | 10.1523/JNEUROSCI.3668-09.2010 |
| PII | 30/4/1301 |
| PMID | 20107057 |
| PMC | PMC6633787 |
| MeSH | Animals Calcium / metabolism Calcium Signaling / physiology* Cell Membrane / genetics Cell Membrane / metabolism Cells, Cultured Central Nervous System / cytology Central Nervous System / growth & development Central Nervous System / metabolism* Drosophila Drosophila Proteins / genetics Drosophila Proteins / metabolism* Flight, Animal / physiology Homeostasis / physiology Inositol 1,4,5-Trisphosphate Receptors / genetics Inositol 1,4,5-Trisphosphate Receptors / metabolism* Insulin / metabolism* Insulin Secretion Intracellular Fluid / metabolism Membrane Proteins / genetics Membrane Proteins / metabolism* Mutation / genetics Neural Pathways / cytology Neural Pathways / growth & development Neural Pathways / metabolism Neurons / cytology Neurons / metabolism* Pupa / genetics Pupa / growth & development Pupa / metabolism Stromal Interaction Molecule 1 |
| IF | 5.674 |
| 引用数 | 32 |
| WOS 分野 | NEUROSCIENCES |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Wikipedia |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 3.0 |
| リソース情報 | |
| ショウジョウバエ | 1063R-2 |