論文 - 詳細
| RRC ID | 2412 |
|---|---|
| 著者 | Niwa Y, Masamizu Y, Liu T, Nakayama R, Deng CX, Kageyama R. |
| タイトル | The initiation and propagation of Hes7 oscillation are cooperatively regulated by Fgf and notch signaling in the somite segmentation clock. |
| ジャーナル | Dev Cell |
| Abstract |
Periodic formation of somites is controlled by the segmentation clock, where the oscillator Hes7 regulates cyclic expression of the Notch modulator Lunatic fringe. Here, we show that Hes7 also regulates cyclic expression of the Fgf signaling inhibitor Dusp4 and links Notch and Fgf oscillations in phase. Strikingly, inactivation of Notch signaling abolishes the propagation but allows the initiation of Hes7 oscillation. By contrast, transient inactivation of Fgf signaling abolishes the initiation, whereas sustained inactivation abolishes both the initiation and propagation of Hes7 oscillation. We thus propose that Hes7 oscillation is initiated by Fgf signaling and propagated/maintained anteriorly by Notch signaling. |
| 巻・号 | 13(2) |
| ページ | 298-304 |
| 公開日 | 2007-8-1 |
| DOI | 10.1016/j.devcel.2007.07.013 |
| PII | S1534-5807(07)00274-2 |
| PMID | 17681139 |
| MeSH | Animals Basic Helix-Loop-Helix Transcription Factors / genetics Basic Helix-Loop-Helix Transcription Factors / metabolism* Biological Clocks* / drug effects Cleavage Stage, Ovum / drug effects Cleavage Stage, Ovum / metabolism* Fibroblast Growth Factors / antagonists & inhibitors Fibroblast Growth Factors / metabolism* Gene Expression Regulation, Developmental / drug effects Mice Mice, Knockout Models, Biological Mutation / genetics Pyrroles / pharmacology Receptors, Notch / antagonists & inhibitors Receptors, Notch / metabolism* Signal Transduction* / drug effects Somites / drug effects Somites / metabolism* Triglycerides / pharmacology gamma-Aminobutyric Acid / analogs & derivatives gamma-Aminobutyric Acid / pharmacology |
| IF | 10.092 |
| 引用数 | 131 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| 実験動物マウス | RBRC01071 RBRC01101 |