| RRC ID |
28103
|
| Author |
Tsukamoto Y, Katayama C, Shinohara M, Shinohara A, Maekawa S, Miyamoto M.
|
| Title |
The small GTPase Rab5 homologue Ypt5 regulates cell morphology, sexual development, ion-stress response and vacuolar formation in fission yeast.
|
| Journal |
Biochem Biophys Res Commun
|
| Abstract |
Inner-membrane transport is critical to cell function. Rab family GTPases play an important role in vesicle transport. In mammalian cells, Rab5 is reported to be involved in the regulation of endosome formation, phagocytosis and chromosome alignment. Here, we examined the role of the fission yeast Rab5 homologue Ypt5 using a point mutant allele. Mutant cells displayed abnormal cell morphology, mating, sporulation, endocytosis, vacuole fusion and responses to ion stress. Our data strongly suggest that fission yeast Rab5 is involved in the regulation of various types of cellular functions.
|
| Volume |
441(4)
|
| Pages |
867-72
|
| Published |
2013-11-29
|
| DOI |
10.1016/j.bbrc.2013.10.158
|
| PII |
S0006-291X(13)01860-3
|
| PMID |
24211211
|
| MeSH |
Endocytosis / genetics
Genes, Mating Type, Fungal
Membrane Fusion
Point Mutation
Schizosaccharomyces / cytology*
Schizosaccharomyces / genetics
Schizosaccharomyces / growth & development*
Schizosaccharomyces pombe Proteins / genetics
Schizosaccharomyces pombe Proteins / metabolism
Schizosaccharomyces pombe Proteins / physiology*
Spores, Fungal / cytology
Spores, Fungal / genetics
Spores, Fungal / growth & development
Stress, Physiological / genetics
Vacuoles / enzymology
Vacuoles / genetics
Vacuoles / physiology*
rab GTP-Binding Proteins / genetics
rab GTP-Binding Proteins / metabolism
rab GTP-Binding Proteins / physiology*
|
| IF |
2.985
|
| Times Cited |
4
|
|
WOS Category
|
BIOPHYSICS
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| Resource |
| Yeast |
TN8
TN29 |
