論文 - 詳細
| RRC ID | 30433 |
|---|---|
| 著者 | Tateno M, Nishida Y, Adachi-Yamada T. |
| タイトル | Regulation of JNK by Src during Drosophila development. |
| ジャーナル | Science |
| Abstract |
In Drosophila, the Jun amino-terminal kinase (JNK) homolog Basket (Bsk) is required for epidermal closure. Mutants for Src42A, a Drosophila c-src protooncogene homolog, are described. Src42A functions in epidermal closure during both embryogenesis and metamorphosis. The severity of the epidermal closure defect in the Src42A mutant depended on the amount of Bsk activity, and the amount of Bsk activity depended on the amount of Src42A. Thus, activation of the Bsk pathway is required downstream of Src42A in epidermal closure. This work confirms mammalian studies that demonstrated a physiological link between Src and JNK. |
| 巻・号 | 287(5451) |
| ページ | 324-7 |
| 公開日 | 2000-1-14 |
| DOI | 10.1126/science.287.5451.324 |
| PII | 8144 |
| PMID | 10634792 |
| MeSH | Actins / metabolism Animals Drosophila / embryology Drosophila / genetics Drosophila / growth & development* Drosophila / metabolism Drosophila Proteins* Enzyme Activation Epidermis / embryology Genes, Insect Insect Proteins / genetics Insect Proteins / metabolism JNK Mitogen-Activated Protein Kinases Metamorphosis, Biological Mitogen-Activated Protein Kinases / metabolism* Phenotype Phosphoprotein Phosphatases / genetics Phosphoprotein Phosphatases / metabolism Phosphorylation Phosphotyrosine / metabolism Point Mutation Protein-Tyrosine Kinases / genetics Protein-Tyrosine Kinases / metabolism* Proto-Oncogene Proteins / genetics Proto-Oncogene Proteins / metabolism* Signal Transduction |
| IF | 41.846 |
| 引用数 | 106 |
| WOS 分野 | CELL BIOLOGY |
| リソース情報 | |
| ショウジョウバエ | DGRC#109634 |