RRC ID 30462
Author Endo K, Aoki T, Yoda Y, Kimura K, Hama C.
Title Notch signal organizes the Drosophila olfactory circuitry by diversifying the sensory neuronal lineages.
Journal Nat Neurosci
Abstract An essential feature of the organization and function of the vertebrate and insect olfactory systems is the generation of a variety of olfactory receptor neurons (ORNs) that have different specificities in regard to both odorant receptor expression and axonal targeting. Yet the underlying mechanisms that generate this neuronal diversity remain elusive. Here we demonstrate that the Notch signal is involved in the diversification of ORNs in Drosophila melanogaster. A systematic clonal analysis showed that a cluster of ORNs housed in each sensillum were differentiated into two classes, depending on the level of Notch activity in their sibling precursors. Notably, ORNs of different classes segregated their axonal projections into distinct domains in the antennal lobes. In addition, both the odorant receptor expression and the axonal targeting of ORNs were specified according to their Notch-mediated identities. Thus, Notch signaling contributes to the diversification of ORNs, thereby regulating multiple developmental events that establish the olfactory map in Drosophila.
Volume 10(2)
Pages 153-60
Published 2007-2-1
DOI 10.1038/nn1832
PII nn1832
PMID 17220884
MeSH Animals Brain / cytology Brain / growth & development Brain / metabolism Cell Differentiation / genetics* Cell Lineage / genetics* Drosophila Proteins / genetics Drosophila Proteins / metabolism Drosophila melanogaster / cytology Drosophila melanogaster / growth & development* Drosophila melanogaster / metabolism Gene Expression Regulation, Developmental / genetics Growth Cones / metabolism Growth Cones / ultrastructure Juvenile Hormones / genetics Juvenile Hormones / metabolism Mutation / genetics Nuclear Proteins / genetics Nuclear Proteins / metabolism Olfactory Pathways / cytology Olfactory Pathways / growth & development* Olfactory Pathways / metabolism Olfactory Receptor Neurons / cytology Olfactory Receptor Neurons / growth & development* Olfactory Receptor Neurons / metabolism Receptors, Notch / genetics Receptors, Notch / metabolism* Receptors, Odorant / genetics Receptors, Odorant / metabolism Signal Transduction / genetics
IF 20.071
Times Cited 75
WOS Category NEUROSCIENCES
Resource
Drosophila DGRC#109584