論文 - 詳細
| RRC ID | 3557 |
|---|---|
| 著者 | Yu X, Odera S, Chuang CH, Lu N, Zhou Z. |
| タイトル | C. elegans Dynamin mediates the signaling of phagocytic receptor CED-1 for the engulfment and degradation of apoptotic cells. |
| ジャーナル | Dev Cell |
| Abstract |
Dynamins are large GTPases that act in multiple vesicular trafficking events. We identified 14 loss-of-function alleles of the C. elegans dynamin gene, dyn-1, that are defective in the removal of apoptotic cells. dyn-1 functions in engulfing cells to control the internalization and degradation of apoptotic cells. dyn-1 acts in the genetic pathway composed of ced-7 (ABC transporter), ced-1 (phagocytic receptor), and ced-6 (CED-1's adaptor). DYN-1 transiently accumulates to the surface of pseudopods in a manner dependent on ced-1, ced-6, and ced-7, but not on ced-5, ced-10, or ced-12. Abnormal vesicle structures accumulate in engulfing cells upon dyn-1 inactivation. dyn-1 and ced-1 mutations block the recruitment of intracellular vesicles to pseudopods and phagosomes. We propose that DYN-1 mediates the signaling of the CED-1 pathway by organizing an intracellular vesicle pool and promoting vesicle delivery to phagocytic cups and phagosomes to support pseudopod extension and apoptotic cell degradation. |
| 巻・号 | 10(6) |
| ページ | 743-57 |
| 公開日 | 2006-6-1 |
| DOI | 10.1016/j.devcel.2006.04.007 |
| PII | S1534-5807(06)00168-7 |
| PMID | 16740477 |
| MeSH | Alleles Amino Acid Sequence Animals Apoptosis* Caenorhabditis elegans / cytology Caenorhabditis elegans / embryology Caenorhabditis elegans / metabolism Caenorhabditis elegans / physiology Caenorhabditis elegans / ultrastructure Caenorhabditis elegans Proteins / metabolism* Conserved Sequence Dynamins / chemistry Dynamins / genetics Dynamins / metabolism* Dynamins / physiology Dynamins / ultrastructure Embryo, Nonmammalian / ultrastructure Helminth Proteins / chemistry Helminth Proteins / genetics Helminth Proteins / metabolism* Helminth Proteins / physiology Helminth Proteins / ultrastructure Membrane Proteins / metabolism* Models, Biological Molecular Sequence Data Mutation Phagocytosis Protein Structure, Tertiary Sequence Homology, Amino Acid Signal Transduction* |
| IF | 10.092 |
| 引用数 | 102 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY CELL BIOLOGY |
| リソース情報 | |
| 線虫 | tm852 |