Reference - Detail
| RRC ID | 412 |
|---|---|
| Author | Ishihara T, Iino Y, Mohri A, Mori I, Gengyo-Ando K, Mitani S, Katsura I. |
| Title | HEN-1, a secretory protein with an LDL receptor motif, regulates sensory integration and learning in Caenorhabditis elegans. |
| Journal | Cell |
| Abstract |
Animals sense many environmental stimuli simultaneously and integrate various sensory signals within the nervous system both to generate proper behavioral responses and also to form relevant memories. HEN-1, a secretory protein with an LDL receptor motif, regulates such processes in Caenorhabditis elegans. The hen-1 mutants show defects in the integration of two sensory signals and in behavioral plasticity by paired stimuli, although their sensation capability seems to be identical to that of the wild-type. The HEN-1 protein is expressed in two pairs of neurons, but expression in other neurons is sufficient for wild-type behavior. In addition, expression of HEN-1 at the adult stage is sufficient. Thus, HEN-1 regulates sensory processing non-cell-autonomously in the mature neuronal circuit. |
| Volume | 109(5) |
| Pages | 639-49 |
| Published | 2002-5-31 |
| DOI | 10.1016/s0092-8674(02)00748-1 |
| PII | S0092867402007481 |
| PMID | 12062106 |
| MeSH | Amino Acid Motifs / genetics Animals Bodily Secretions / physiology Caenorhabditis elegans / cytology Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / isolation & purification* Caenorhabditis elegans Proteins / metabolism Evolution, Molecular Gene Expression Regulation / physiology Homeodomain Proteins / genetics Learning / physiology* Nerve Tissue Proteins / genetics Nerve Tissue Proteins / isolation & purification* Nerve Tissue Proteins / metabolism Nervous System / cytology Nervous System / growth & development* Nervous System / metabolism Neural Pathways / cytology Neural Pathways / growth & development* Neural Pathways / metabolism Neurons / cytology Neurons / metabolism* Neuropeptides / deficiency Neuropeptides / genetics Phenotype Phylogeny Receptors, LDL / chemistry Receptors, LDL / genetics Sensation / genetics* Signal Transduction / genetics |
| IF | 38.637 |
| Times Cited | 96 |
| WOS Category | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| Resource | |
| C.elegans | tm501 |