RRC ID 419
著者 Wang X, Wu YC, Fadok VA, Lee MC, Gengyo-Ando K, Cheng LC, Ledwich D, Hsu PK, Chen JY, Chou BK, Henson P, Mitani S, Xue D.
タイトル Cell corpse engulfment mediated by C. elegans phosphatidylserine receptor through CED-5 and CED-12.
ジャーナル Science
Abstract During apoptosis, phosphatidylserine, which is normally restricted to the inner leaflet of the plasma membrane, is exposed on the surface of apoptotic cells and has been suggested to act as an "eat-me" signal to trigger phagocytosis. It is unclear how phagocytes recognize phosphatidylserine. Recently, a putative phosphatidylserine receptor (PSR) was identified and proposed to mediate recognition of phosphatidylserine and phagocytosis. We report that psr-1, the Caenorhabditis elegans homolog of PSR, is important for cell corpse engulfment. In vitro PSR-1 binds preferentially phosphatidylserine or cells with exposed phosphatidylserine. In C. elegans, PSR-1 acts in the same cell corpse engulfment pathway mediated by intracellular signaling molecules CED-2 (homologous to the human CrkII protein), CED-5 (DOCK180), CED-10 (Rac GTPase), and CED-12 (ELMO), possibly through direct interaction with CED-5 and CED-12. Our findings suggest that PSR-1 is likely an upstream receptor for the signaling pathway containing CED-2, CED-5, CED-10, and CED-12 proteins and plays an important role in recognizing phosphatidylserine during phagocytosis.
巻・号 302(5650)
ページ 1563-6
公開日 2003-11-28
DOI 10.1126/science.1087641
PII 302/5650/1563
PMID 14645848
MeSH Adaptor Proteins, Signal Transducing* Amino Acid Sequence Animals Apoptosis* Apoptosis Regulatory Proteins Caenorhabditis elegans / cytology Caenorhabditis elegans / embryology Caenorhabditis elegans / metabolism Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Carrier Proteins / genetics Carrier Proteins / metabolism* Cytoskeletal Proteins* Embryo, Nonmammalian / cytology Embryo, Nonmammalian / metabolism Embryonic Development Humans Jumonji Domain-Containing Histone Demethylases Membrane Proteins / genetics Membrane Proteins / metabolism* Molecular Sequence Data Mutation Phagocytosis* Phosphatidylserines / metabolism Protein Binding Receptors, Cell Surface / genetics Receptors, Cell Surface / metabolism* Recombinant Fusion Proteins / metabolism Recombinant Proteins / metabolism Signal Transduction rac GTP-Binding Proteins / genetics rac GTP-Binding Proteins / metabolism
IF 41.846
引用数 149
WOS 分野 CELL BIOLOGY
リソース情報
線虫 tm469