論文 - 詳細
| RRC ID | 4231 |
|---|---|
| 著者 | Goodyer W, Kaitna S, Couteau F, Ward JD, Boulton SJ, Zetka M. |
| タイトル | HTP-3 links DSB formation with homolog pairing and crossing over during C. elegans meiosis. |
| ジャーナル | Dev Cell |
| Abstract |
Repair of the programmed meiotic double-strand breaks (DSBs) that initiate recombination must be coordinated with homolog pairing to generate crossovers capable of directing chromosome segregation. Chromosome pairing and synapsis proceed independently of recombination in worms and flies, suggesting a paradoxical lack of coregulation. Here, we find that the meiotic axis component HTP-3 links DSB formation with homolog pairing and synapsis. HTP-3 forms complexes with the DSB repair components MRE-11/RAD-50 and the meiosis-specific axis component HIM-3. Loss of htp-3 or mre-11 recapitulates meiotic phenotypes consistent with a failure to generate DSBs, suggesting that HTP-3 associates with MRE-11/RAD-50 in a complex required for meiotic DSB formation. Loss of HTP-3 eliminates HIM-3 localization to axes and HIM-3-dependent homolog alignment, synapsis, and crossing over. Our study reveals a mechanism for coupling meiotic DSB formation with homolog pairing through the essential participation of an axis component with complexes mediating both processes. |
| 巻・号 | 14(2) |
| ページ | 263-74 |
| 公開日 | 2008-2-1 |
| DOI | 10.1016/j.devcel.2007.11.016 |
| PII | S1534-5807(07)00438-8 |
| PMID | 18267094 |
| MeSH | Animals Caenorhabditis elegans / cytology* Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / metabolism* Cell Cycle Proteins / metabolism* Chromatin / metabolism Chromosome Pairing* Chromosome Positioning Crossing Over, Genetic* DNA Breaks, Double-Stranded* DNA Repair Meiosis* Mutation / genetics Protein Binding Protein Transport RNA Interference |
| IF | 10.092 |
| 引用数 | 109 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 各媒体での言及数の合計 | 0 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1086 |