論文 - 詳細
RRC ID | 428 |
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著者 | Ikegami R, Zheng H, Ong SH, Culotti J. |
タイトル | Integration of semaphorin-2A/MAB-20, ephrin-4, and UNC-129 TGF-beta signaling pathways regulates sorting of distinct sensory rays in C. elegans. |
ジャーナル | Dev Cell |
Abstract |
Semaphorins and ephrins are axon guidance cues. In C. elegans, semaphorin-2a/mab-20 and ephrin-4/efn-4/mab-26 also regulate cell sorting to form distinct rays in the male tail. Several erf (enhancer of ray fusion) mutations were identified in a mab-20 enhancer screen. Mutants of plexin-2 (plx-2) and unc-129, which encodes an axon guiding TGF-beta, were also found to be erfs. Genetic analyses show that plx-2 and mab-20 function in the same pathway, as expected if PLX-2 is a receptor for MAB-20. Surprisingly, MAB-20 also signals in a parallel pathway that requires efn-4. This signal utilizes a non-plexin receptor. The expression of plx-2, efn-4, and unc-129 in subsets of 3-cell sensory ray clusters likely mediates the ray-specific cell sorting functions of the ubiquitously expressed mab-20. We present a model for the integrated control of TGF-beta, semaphorin, and ephrin signaling in the sorting of cell clusters into distinct rays in the developing male tail. |
巻・号 | 6(3) |
ページ | 383-95 |
公開日 | 2004-3-1 |
DOI | 10.1016/s1534-5807(04)00057-7 |
PII | S1534-5807(04)00057-7 |
PMID | 15030761 |
MeSH | Animals Animals, Genetically Modified Caenorhabditis elegans / embryology Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / physiology* Cell Cycle Proteins / genetics Cell Cycle Proteins / metabolism Chi-Square Distribution Chromosome Mapping / methods Cloning, Molecular DNA Mutational Analysis Enhancer Elements, Genetic Ephrin-A4 / genetics Ephrin-A4 / physiology* Ephrins / physiology Gene Expression Regulation, Developmental Green Fluorescent Proteins Immunohistochemistry / methods Luminescent Proteins / metabolism Male Membrane Proteins / genetics Membrane Proteins / physiology* Models, Molecular Mutagenesis, Insertional / methods Mutation Nerve Tissue Proteins / genetics Nerve Tissue Proteins / physiology* Protein Serine-Threonine Kinases / genetics Protein Serine-Threonine Kinases / metabolism Sense Organs / physiology* Sequence Analysis, DNA Signal Transduction / physiology* Transforming Growth Factor beta / genetics Transforming Growth Factor beta / physiology* Xenopus Proteins / genetics Xenopus Proteins / metabolism |
IF | 10.092 |
引用数 | 33 |
リソース情報 | |
線虫 | tm729 |