RRC ID |
43690
|
著者 |
Inoue Y, Hasegawa S, Yamada T, Date Y, Mizutani H, Nakata S, Matsunaga K, Akamatsu H.
|
タイトル |
Bimodal effect of retinoic acid on melanocyte differentiation identified by time-dependent analysis.
|
ジャーナル |
Pigment Cell Melanoma Res
|
Abstract |
Retinoic acid (RA) is considered to control melanocytes; however, its precise mechanism remains unclear because of a bimodal effect, which promotes or inhibits melanin synthesis depending on the cell type, culture condition of melanocytes and skin conditions. In this study, we examined the effects of RA throughout each stage of differentiation of melanocytes using a mouse embryonic stem cell culture system to induce melanocytes. The results showed that RA has significantly different effects depending on the stage of differentiation of melanocytes. More specifically, RA promoted differentiation in earlier stages, wherein embryonic stem cells became melanoblasts via neural crest cells, and inhibited differentiation in later stages, wherein melanoblasts became melanocytes. It was revealed for the first time that melanocytes show markedly different reactions to RA depending on the stage of differentiation.
|
巻・号 |
25(3)
|
ページ |
299-311
|
公開日 |
2012-5-1
|
DOI |
10.1111/j.1755-148X.2012.00988.x
|
PMID |
22364180
|
MeSH |
Animals
Cell Differentiation / drug effects*
Cell Differentiation / genetics
Cells, Cultured
Drug Evaluation, Preclinical
Gene Expression Profiling
Gene Expression Regulation / drug effects
Humans
Melanins / biosynthesis
Melanocytes / drug effects*
Melanocytes / metabolism
Melanocytes / physiology
Melanocytes / ultrastructure
Mice
Mice, Inbred C57BL
Real-Time Polymerase Chain Reaction / methods
Signal Transduction / drug effects
Signal Transduction / genetics
Signal Transduction / physiology
Stem Cells
Time Factors
Tretinoin / pharmacology*
|
IF |
3.683
|
引用数 |
11
|
WOS 分野
|
DERMATOLOGY
ONCOLOGY
CELL BIOLOGY
|
リソース情報 |
ヒト・動物細胞 |
TT2(AES0014) |