RRC ID |
44526
|
著者 |
Akiyama M, Ozaki K, Kawano T, Yamada O, Kawauchi K, Ida H, Yamada H.
|
タイトル |
Telomerase activation as a repair response to radiation-induced DNA damage in Y79 retinoblastoma cells.
|
ジャーナル |
Cancer Lett
|
Abstract |
The molecular mechanism of telomerase activation induced by ionizing radiation (IR) remains poorly understood. We demonstrate that DNA damage induced by IR at doses of 2-5 Gy triggers activation of Akt, predominant to that of protein phosphatase 2A (PP2A), resulting in human telomerase reverse transcriptase (hTERT) phosphorylation and increased telomerase activity in Y79 cells. DNA damage induced by IR at doses greater than 10 Gy might trigger PP2A activation, predominant to that of Akt, resulting in hTERT dephosphorylation and decreased telomerase activity. Our results suggest that differential activation of Akt and PP2A may be responsible for telomerase regulation.
|
巻・号 |
340(1)
|
ページ |
82-7
|
公開日 |
2013-10-28
|
DOI |
10.1016/j.canlet.2013.07.003
|
PII |
S0304-3835(13)00508-9
|
PMID |
23850566
|
MeSH |
Androstadienes / pharmacology
Apoptosis / radiation effects
Cell Line, Tumor
DNA Damage*
DNA Repair*
Enzyme Activation
G2 Phase Cell Cycle Checkpoints / radiation effects
Gene Expression
Histones / metabolism
Humans
MAP Kinase Signaling System
Okadaic Acid / pharmacology
Phosphorylation
Protein Processing, Post-Translational
Retinoblastoma
Telomerase / genetics
Telomerase / metabolism*
Tumor Suppressor Protein p53 / metabolism
Wortmannin
|
IF |
7.36
|
引用数 |
14
|
WOS 分野
|
ONCOLOGY
|
リソース情報 |
ヒト・動物細胞 |
Y79 |