論文 - 詳細
| RRC ID | 45718 |
|---|---|
| 著者 | de Albuquerque BF, Luteijn MJ, Cordeiro Rodrigues RJ, van Bergeijk P, Waaijers S, Kaaij LJ, Klein H, Boxem M, Ketting RF. |
| タイトル | PID-1 is a novel factor that operates during 21U-RNA biogenesis in Caenorhabditis elegans. |
| ジャーナル | Genes Dev |
| Abstract |
The Piwi-piRNA pathway represents a small RNA-based mechanism responsible for the recognition and silencing of invading DNA. Biogenesis of piRNAs (21U-RNAs) is poorly understood. In Caenorhabditis elegans, the piRNA-binding Argonaute protein PRG-1 is the only known player acting downstream from precursor transcription. From a screen aimed at the isolation of piRNA-induced silencing-defective (Pid) mutations, we identified, among known Piwi pathway components, PID-1 as a novel player. PID-1 is a mostly cytoplasmic, germline-specific factor essential for 21U-RNA biogenesis, affecting an early step in the processing or transport of 21U precursor transcripts. We also show that maternal 21U-RNAs are essential to initiate silencing. |
| 巻・号 | 28(7) |
| ページ | 683-8 |
| 公開日 | 2014-4-1 |
| DOI | 10.1101/gad.238220.114 |
| PII | 28/7/683 |
| PMID | 24696453 |
| PMC | PMC4015495 |
| MeSH | Animals Argonaute Proteins / genetics Argonaute Proteins / metabolism Caenorhabditis elegans / genetics* Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / genetics* Caenorhabditis elegans Proteins / metabolism* Methylation Mutation Protein Precursors / metabolism RNA Interference / physiology RNA, Small Interfering / biosynthesis* Transgenes / genetics |
| IF | 9.527 |
| 引用数 | 14 |
| WOS 分野 | GENETICS & HEREDITY DEVELOPMENTAL BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| 線虫 | tm1200 |