RRC ID 45737
著者 Guo M, Wu TH, Song YX, Ge MH, Su CM, Niu WP, Li LL, Xu ZJ, Ge CL, Al-Mhanawi MT, Wu SP, Wu ZX.
タイトル Reciprocal inhibition between sensory ASH and ASI neurons modulates nociception and avoidance in Caenorhabditis elegans.
ジャーナル Nat Commun
Abstract Sensory modulation is essential for animal sensations, behaviours and survival. Peripheral modulations of nociceptive sensations and aversive behaviours are poorly understood. Here we identify a biased cross-inhibitory neural circuit between ASH and ASI sensory neurons. This inhibition is essential to drive normal adaptive avoidance of a CuSO4 (Cu(2+)) challenge in Caenorhabditis elegans. In the circuit, ASHs respond to Cu(2+) robustly and suppress ASIs via electro-synaptically exciting octopaminergic RIC interneurons, which release octopamine (OA), and neuroendocrinally inhibit ASI by acting on the SER-3 receptor. In addition, ASIs sense Cu(2+) and permit a rapid onset of Cu(2+)-evoked responses in Cu(2+)-sensitive ADF neurons via neuropeptides possibly, to inhibit ASHs. ADFs function as interneurons to mediate ASI inhibition of ASHs by releasing serotonin (5-HT) that binds with the SER-5 receptor on ASHs. This elaborate modulation among sensory neurons via reciprocal inhibition fine-tunes the nociception and avoidance behaviour.
巻・号 6
ページ 5655
公開日 2015-1-13
DOI 10.1038/ncomms6655
PII ncomms6655
PMID 25585042
MeSH Animals Avoidance Learning* Behavior, Animal Biomechanical Phenomena Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / metabolism Calcium / metabolism Copper / chemistry Copper Sulfate / chemistry Genotype Interneurons / physiology* Microscopy, Confocal Mutation Neurons / physiology* Neuropeptides / chemistry Nociception / physiology* Nociceptors / metabolism Octopamine / chemistry Sensory Receptor Cells / physiology Serotonin / chemistry Signal Transduction / physiology*
IF 12.121
引用数 28
WOS 分野 NEUROSCIENCES
リソース情報
線虫 tm2647 tm1377 tm1815