Reference - Detail
|Author||Mentink RA, Middelkoop TC, Rella L, Ji N, Tang CY, Betist MC, van Oudenaarden A, Korswagen HC.|
|Title||Cell intrinsic modulation of Wnt signaling controls neuroblast migration in C. elegans.|
Members of the Wnt family of secreted signaling proteins are key regulators of cell migration and axon guidance. In the nematode C. elegans, the migration of the QR neuroblast descendants requires multiple Wnt ligands and receptors. We found that the migration of the QR descendants is divided into three sequential phases that are each mediated by a distinct Wnt signaling mechanism. Importantly, the transition from the first to the second phase, which is the main determinant of the final position of the QR descendants along the anteroposterior body axis, is mediated through a cell-autonomous process in which the time-dependent expression of a Wnt receptor turns on the canonical Wnt/β-catenin signaling response that is required to terminate long-range anterior migration. Our results show that, in addition to direct guidance of cell migration by Wnt morphogenic gradients, cell migration can also be controlled indirectly through cell-intrinsic modulation of Wnt signaling responses.
|MeSH||Animals Caenorhabditis elegans / cytology Caenorhabditis elegans / growth & development* Caenorhabditis elegans Proteins / biosynthesis Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Cell Movement / genetics* Cell Polarity Frizzled Receptors / biosynthesis Frizzled Receptors / metabolism Gene Expression Regulation / genetics Glycoproteins / biosynthesis Glycoproteins / genetics Glycoproteins / metabolism Homeodomain Proteins / genetics Intracellular Signaling Peptides and Proteins / biosynthesis Intracellular Signaling Peptides and Proteins / genetics Intracellular Signaling Peptides and Proteins / metabolism Membrane Proteins / genetics Membrane Proteins / metabolism Morphogenesis Neural Stem Cells / cytology Neural Stem Cells / physiology* Phosphoproteins / metabolism Receptor Tyrosine Kinase-like Orphan Receptors / genetics Receptor Tyrosine Kinase-like Orphan Receptors / metabolism Receptors, G-Protein-Coupled / biosynthesis Transcription Factors / genetics Wnt Proteins / biosynthesis Wnt Proteins / metabolism* Wnt Signaling Pathway / genetics* beta Catenin / metabolism|
|WOS Category||DEVELOPMENTAL BIOLOGY CELL BIOLOGY|