RRC ID 45921
Author Anderson A, Laurenson-Schafer H, Partridge FA, Hodgkin J, McMullan R.
Title Serotonergic chemosensory neurons modify the C. elegans immune response by regulating G-protein signaling in epithelial cells.
Journal PLoS Pathog
Abstract The nervous and immune systems influence each other, allowing animals to rapidly protect themselves from changes in their internal and external environment. However, the complex nature of these systems in mammals makes it difficult to determine how neuronal signaling influences the immune response. Here we show that serotonin, synthesized in Caenorhabditis elegans chemosensory neurons, modulates the immune response. Serotonin released from these cells acts, directly or indirectly, to regulate G-protein signaling in epithelial cells. Signaling in these cells is required for the immune response to infection by the natural pathogen Microbacterium nematophilum. Here we show that serotonin signaling suppresses the innate immune response and limits the rate of pathogen clearance. We show that C. elegans uses classical neurotransmitters to alter the immune response. Serotonin released from sensory neurons may function to modify the immune system in response to changes in the animal's external environment such as the availability, or quality, of food.
Volume 9(12)
Pages e1003787
Published 2013-1-1
DOI 10.1371/journal.ppat.1003787
PMID 24348250
PMC PMC3861540
MeSH Animals Animals, Genetically Modified Caenorhabditis elegans / genetics Caenorhabditis elegans / immunology* Caenorhabditis elegans / microbiology Caenorhabditis elegans Proteins / genetics* Caenorhabditis elegans Proteins / metabolism Epithelial Cells / immunology* Epithelial Cells / metabolism GTP-Binding Protein alpha Subunits, Gi-Go / genetics* GTP-Binding Protein alpha Subunits, Gi-Go / metabolism GTP-Binding Proteins / genetics GTP-Binding Proteins / metabolism Gene Expression Regulation Immunity, Innate / drug effects Immunity, Innate / genetics* RGS Proteins / genetics* RGS Proteins / metabolism Sensory Receptor Cells / drug effects Sensory Receptor Cells / metabolism Serotonergic Neurons / immunology* Serotonin / pharmacology Signal Transduction / drug effects Signal Transduction / genetics Signal Transduction / immunology
IF 6.218
Times Cited 19
C.elegans tm1325 tm13325