論文 - 詳細
| RRC ID | 45947 |
|---|---|
| 著者 | Chen YZ, Mapes J, Lee ES, Skeen-Gaar RR, Xue D. |
| タイトル | Caspase-mediated activation of Caenorhabditis elegans CED-8 promotes apoptosis and phosphatidylserine externalization. |
| ジャーナル | Nat Commun |
| Abstract |
During apoptosis, phosphatidylserine (PS), normally restricted to the inner leaflet of the plasma membrane, is exposed on the surface of apoptotic cells and serves as an 'eat-me' signal to trigger phagocytosis. It is poorly understood how PS exposure is activated in apoptotic cells. Here we report that CED-8, a Caenorhabditis elegans protein implicated in controlling the kinetics of apoptosis and a homologue of the XK family proteins, is a substrate of the CED-3 caspase. Cleavage of CED-8 by CED-3 activates its proapoptotic function and generates a carboxyl-terminal cleavage product, acCED-8, that promotes PS externalization in apoptotic cells and can induce ectopic PS exposure in living cells. Consistent with its role in promoting PS externalization in apoptotic cells, ced-8 is important for cell corpse engulfment in C. elegans. Our finding identifies a crucial link between caspase activation and PS externalization, which triggers phagocytosis of apoptotic cells. |
| 巻・号 | 4 |
| ページ | 2726 |
| 公開日 | 2013-1-1 |
| DOI | 10.1038/ncomms3726 |
| PII | ncomms3726 |
| PMID | 24225442 |
| PMC | PMC3939056 |
| MeSH | Alleles Animals Animals, Genetically Modified Apoptosis* Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / metabolism* Caspases / metabolism* Cell Membrane / metabolism Enzyme Activation Gene Expression Regulation, Developmental Green Fluorescent Proteins / metabolism Heat-Shock Proteins / metabolism Membrane Proteins / metabolism* Mutation Phagocytosis Phosphatidylserines / metabolism* |
| IF | 12.121 |
| 引用数 | 41 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm2078 tm3117 |