論文 - 詳細
| RRC ID | 46036 |
|---|---|
| 著者 | Lapierre LR, De Magalhaes Filho CD, McQuary PR, Chu CC, Visvikis O, Chang JT, Gelino S, Ong B, Davis AE, Irazoqui JE, Dillin A, Hansen M. |
| タイトル | The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans. |
| ジャーナル | Nat Commun |
| Abstract |
Autophagy is a cellular recycling process that has an important anti-aging role, but the underlying molecular mechanism is not well understood. The mammalian transcription factor EB (TFEB) was recently shown to regulate multiple genes in the autophagy process. Here we show that the predicted TFEB orthologue HLH-30 regulates autophagy in Caenorhabditis elegans and, in addition, has a key role in lifespan determination. We demonstrate that hlh-30 is essential for the extended lifespan of Caenorhabditis elegans in six mechanistically distinct longevity models, and overexpression of HLH-30 extends lifespan. Nuclear localization of HLH-30 is increased in all six Caenorhabditis elegans models and, notably, nuclear TFEB levels are augmented in the livers of mice subjected to dietary restriction, a known longevity-extending regimen. Collectively, our results demonstrate a conserved role for HLH-30 and TFEB in autophagy, and possibly longevity, and identify HLH-30 as a uniquely important transcription factor for lifespan modulation in Caenorhabditis elegans. |
| 巻・号 | 4 |
| ページ | 2267 |
| 公開日 | 2013-1-1 |
| DOI | 10.1038/ncomms3267 |
| PII | ncomms3267 |
| PMID | 23925298 |
| PMC | PMC3866206 |
| MeSH | Animals Autophagy* Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / metabolism Basic Helix-Loop-Helix Transcription Factors / metabolism* Caenorhabditis elegans / cytology* Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / metabolism* Cell Nucleus / metabolism Diet Female Longevity* Lysosomes / metabolism Male Mice Mice, Inbred C57BL Models, Animal Mutation / genetics Sequence Homology, Amino Acid |
| IF | 12.121 |
| 引用数 | 181 |
| WOS 分野 | CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | News |
| 各媒体での言及数の合計 | 18 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1978 |