| RRC ID |
46036
|
| 著者 |
Lapierre LR, De Magalhaes Filho CD, McQuary PR, Chu CC, Visvikis O, Chang JT, Gelino S, Ong B, Davis AE, Irazoqui JE, Dillin A, Hansen M.
|
| タイトル |
The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans.
|
| ジャーナル |
Nat Commun
|
| Abstract |
Autophagy is a cellular recycling process that has an important anti-aging role, but the underlying molecular mechanism is not well understood. The mammalian transcription factor EB (TFEB) was recently shown to regulate multiple genes in the autophagy process. Here we show that the predicted TFEB orthologue HLH-30 regulates autophagy in Caenorhabditis elegans and, in addition, has a key role in lifespan determination. We demonstrate that hlh-30 is essential for the extended lifespan of Caenorhabditis elegans in six mechanistically distinct longevity models, and overexpression of HLH-30 extends lifespan. Nuclear localization of HLH-30 is increased in all six Caenorhabditis elegans models and, notably, nuclear TFEB levels are augmented in the livers of mice subjected to dietary restriction, a known longevity-extending regimen. Collectively, our results demonstrate a conserved role for HLH-30 and TFEB in autophagy, and possibly longevity, and identify HLH-30 as a uniquely important transcription factor for lifespan modulation in Caenorhabditis elegans.
|
| 巻・号 |
4
|
| ページ |
2267
|
| 公開日 |
2013-1-1
|
| DOI |
10.1038/ncomms3267
|
| PII |
ncomms3267
|
| PMID |
23925298
|
| PMC |
PMC3866206
|
| MeSH |
Animals
Autophagy*
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / metabolism
Basic Helix-Loop-Helix Transcription Factors / metabolism*
Caenorhabditis elegans / cytology*
Caenorhabditis elegans / physiology*
Caenorhabditis elegans Proteins / metabolism*
Cell Nucleus / metabolism
Diet
Female
Longevity*
Lysosomes / metabolism
Male
Mice
Mice, Inbred C57BL
Models, Animal
Mutation / genetics
Sequence Homology, Amino Acid
|
| IF |
12.121
|
| 引用数 |
181
|
|
WOS 分野
|
CELL BIOLOGY
|
| リソース情報 |
| 線虫 |
tm1978 |
