RRC ID 46098
著者 Greer EL, Maures TJ, Ucar D, Hauswirth AG, Mancini E, Lim JP, Benayoun BA, Shi Y, Brunet A.
タイトル Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans.
ジャーナル Nature
Abstract Chromatin modifiers regulate lifespan in several organisms, raising the question of whether changes in chromatin states in the parental generation could be incompletely reprogrammed in the next generation and thereby affect the lifespan of descendants. The histone H3 lysine 4 trimethylation (H3K4me3) complex, composed of ASH-2, WDR-5 and the histone methyltransferase SET-2, regulates Caenorhabditis elegans lifespan. Here we show that deficiencies in the H3K4me3 chromatin modifiers ASH-2, WDR-5 or SET-2 in the parental generation extend the lifespan of descendants up until the third generation. The transgenerational inheritance of lifespan extension by members of the ASH-2 complex is dependent on the H3K4me3 demethylase RBR-2, and requires the presence of a functioning germline in the descendants. Transgenerational inheritance of lifespan is specific for the H3K4me3 methylation complex and is associated with epigenetic changes in gene expression. Thus, manipulation of specific chromatin modifiers only in parents can induce an epigenetic memory of longevity in descendants.
巻・号 479(7373)
ページ 365-71
公開日 2011-10-19
DOI 10.1038/nature10572
PII nature10572
PMID 22012258
PMC PMC3368121
MeSH Animals Caenorhabditis elegans / genetics* Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Chromatin / metabolism Epigenesis, Genetic / genetics* Female Gene Expression Regulation Gene Knockdown Techniques Histone Demethylases / genetics Histone Demethylases / metabolism Histone-Lysine N-Methyltransferase / deficiency Histone-Lysine N-Methyltransferase / genetics Histone-Lysine N-Methyltransferase / metabolism Histones Inheritance Patterns* Longevity / genetics* Longevity / physiology Male Methylation Mutation / genetics Nuclear Proteins / genetics Nuclear Proteins / metabolism Pedigree Retinoblastoma-Binding Protein 2 / genetics Retinoblastoma-Binding Protein 2 / metabolism
IF 42.779
引用数 353
WOS 分野 CELL BIOLOGY
リソース情報
線虫 tm1231