Reference - Detail
| RRC ID | 46158 |
|---|---|
| Author | Luciani GM, Magomedova L, Puckrin R, Urbanus ML, Wallace IM, Giaever G, Nislow C, Cummins CL, Roy PJ. |
| Title | Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans. |
| Journal | Nat Chem Biol |
| Abstract |
The DAF-9 cytochrome P450 is a key regulator of dauer formation, developmental timing and longevity in the nematode Caenorhabditis elegans. Here we describe the first identified chemical inhibitor of DAF-9 and the first reported small-molecule tool that robustly induces dauer formation in typical culture conditions. This molecule (called dafadine) also inhibits the mammalian ortholog of DAF-9(CYP27A1), suggesting that dafadine can be used to interrogate developmental control and longevity in other animals. |
| Volume | 7(12) |
| Pages | 891-3 |
| Published | 2011-11-6 |
| DOI | 10.1038/nchembio.698 |
| PII | nchembio.698 |
| PMID | 22057127 |
| MeSH | Animals Caenorhabditis elegans / drug effects* Caenorhabditis elegans / growth & development* Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins / antagonists & inhibitors* Caenorhabditis elegans Proteins / metabolism Cytochrome P-450 Enzyme Inhibitors* Cytochrome P-450 Enzyme System / metabolism Enzyme Activation / drug effects Enzyme Inhibitors / chemistry Enzyme Inhibitors / pharmacology* Isoxazoles / chemistry Isoxazoles / pharmacology* Larva / drug effects Longevity / drug effects* Molecular Structure Piperidines / chemistry Piperidines / pharmacology* Pyridines / chemistry Pyridines / pharmacology* Stereoisomerism Structure-Activity Relationship |
| IF | 12.587 |
| Times Cited | 16 |
| WOS Category | BIOCHEMISTRY & MOLECULAR BIOLOGY |
| Resource | |
| C.elegans | NA |