| RRC ID |
46458
|
| 著者 |
Unsoeld T, Park JO, Hutter H.
|
| タイトル |
Discoidin domain receptors guide axons along longitudinal tracts in C. elegans.
|
| ジャーナル |
Dev Biol
|
| Abstract |
Discoidin domain receptors are a family of receptor tyrosine kinases activated by collagens. Here we characterize the role of the two discoidin domain receptors, ddr-1 and ddr-2, of the nematode C. elegans during nervous system development. ddr-2 mutant animals exhibit axon guidance defects in major longitudinal tracts most prominently in the ventral nerve cord. ddr-1 mutants show no significant phenotype on their own but significantly enhance guidance defects of ddr-2 in double mutants. ddr-1 and ddr-2 GFP-reporter constructs are expressed in neurons with axons in all affected nerve tracts. DDR-1 and DDR-2 GFP fusion proteins localize to axons. DDR-2 is required cell-autonomously in the PVPR neuron for the guidance of the PVPR pioneer axon, which establishes the left ventral nerve cord tract and serves as substrate for later outgrowing follower axons. Our results provide the first insight on discoidin domain receptor function in invertebrates and establish a novel role for discoidin domain receptors in axon navigation and axon tract formation.
|
| 巻・号 |
374(1)
|
| ページ |
142-52
|
| 公開日 |
2013-2-1
|
| DOI |
10.1016/j.ydbio.2012.11.001
|
| PII |
S0012-1606(12)00604-5
|
| PMID |
23147028
|
| MeSH |
Alleles
Animals
Axons / metabolism*
Axons / physiology
Cadherins / metabolism
Caenorhabditis elegans
Caenorhabditis elegans Proteins / metabolism
Collagen / chemistry
Discoidin Domain Receptors
Genes, Reporter
Membrane Glycoproteins / metabolism
Models, Biological
Mutation
Neurons / metabolism
Phenotype
Phylogeny
Protein Structure, Tertiary
Receptor Protein-Tyrosine Kinases / chemistry*
Receptor Protein-Tyrosine Kinases / metabolism
Receptors, Mitogen / chemistry*
Receptors, Mitogen / metabolism
Transgenes
|
| IF |
2.896
|
| 引用数 |
11
|
|
WOS 分野
|
DEVELOPMENTAL BIOLOGY
|
| リソース情報 |
| 線虫 |
tm382
tm797 |
