Reference - Detail
| RRC ID | 53956 |
|---|---|
| Author | Ferrandiz N, Barroso C, Telecan O, Shao N, Kim HM, Testori S, Faull P, Cutillas P, Snijders AP, Colaiácovo MP, Martinez-Perez E. |
| Title | Spatiotemporal regulation of Aurora B recruitment ensures release of cohesion during C. elegans oocyte meiosis. |
| Journal | Nat Commun |
| Abstract |
The formation of haploid gametes from diploid germ cells requires the regulated two-step release of sister chromatid cohesion (SCC) during the meiotic divisions. Here, we show that phosphorylation of cohesin subunit REC-8 by Aurora B promotes SCC release at anaphase I onset in C. elegans oocytes. Aurora B loading to chromatin displaying Haspin-mediated H3 T3 phosphorylation induces spatially restricted REC-8 phosphorylation, preventing full SCC release during anaphase I. H3 T3 phosphorylation is locally antagonized by protein phosphatase 1, which is recruited to chromosomes by HTP-1/2 and LAB-1. Mutating the N terminus of HTP-1 causes ectopic H3 T3 phosphorylation, triggering precocious SCC release without impairing earlier HTP-1 roles in homolog pairing and recombination. CDK-1 exerts temporal regulation of Aurora B recruitment, coupling REC-8 phosphorylation to oocyte maturation. Our findings elucidate a complex regulatory network that uses chromosome axis components, H3 T3 phosphorylation, and cell cycle regulators to ensure accurate chromosome segregation during oogenesis. |
| Volume | 9(1) |
| Pages | 834 |
| Published | 2018-2-26 |
| DOI | 10.1038/s41467-018-03229-5 |
| PII | 10.1038/s41467-018-03229-5 |
| PMID | 29483514 |
| PMC | PMC5827026 |
| MeSH | Anaphase Animals Aurora Kinase B / genetics* Aurora Kinase B / metabolism Caenorhabditis elegans / cytology Caenorhabditis elegans / genetics* Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins / genetics* Caenorhabditis elegans Proteins / metabolism Cell Cycle Proteins / genetics* Cell Cycle Proteins / metabolism Chromatids / metabolism Chromatids / ultrastructure Chromatin / metabolism Chromatin / ultrastructure Chromosomal Proteins, Non-Histone / genetics* Chromosomal Proteins, Non-Histone / metabolism Chromosome Segregation Cohesins Gene Expression Regulation Hermaphroditic Organisms / cytology Hermaphroditic Organisms / genetics* Hermaphroditic Organisms / metabolism Histones / genetics Histones / metabolism Oocytes / cytology Oocytes / metabolism* Oogenesis / genetics Phosphorylation Protein Phosphatase 1 / genetics Protein Phosphatase 1 / metabolism Protein Serine-Threonine Kinases / genetics Protein Serine-Threonine Kinases / metabolism |
| IF | 12.121 |
| Times Cited | 13 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 11 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm1791 tm1395 tm2543 |