| RRC ID |
5450
|
| Author |
Mariño G, Ugalde AP, Salvador-Montoliu N, Varela I, Quirós PM, Cadiñanos J, van der Pluijm I, Freije JM, López-Otín C.
|
| Title |
Premature aging in mice activates a systemic metabolic response involving autophagy induction.
|
| Journal |
Hum Mol Genet
|
| Abstract |
Autophagy is a highly regulated intracellular process involved in the turnover of most cellular constituents and in the maintenance of cellular homeostasis. It is well-established that the basal autophagic activity of living cells decreases with age, thus contributing to the accumulation of damaged macromolecules during aging. Conversely, the activity of this catabolic pathway is required for lifespan extension in animal models such as Caenorhabditis elegans and Drosophila melanogaster. In this work, we describe the unexpected finding that Zmpste24-null mice, which show accelerated aging and are a reliable model of human Hutchinson-Gilford progeria, exhibit an extensive basal activation of autophagy instead of the characteristic decline in this process occurring during normal aging. We also show that this autophagic increase is associated with a series of changes in lipid and glucose metabolic pathways, which resemble those occurring in diverse situations reported to prolong lifespan. These Zmpste24(-/-) mice metabolic alterations are also linked to substantial changes in circulating blood parameters, such as leptin, glucose, insulin or adiponectin which in turn lead to peripheral LKB1-AMPK activation and mTOR inhibition. On the basis of these results, we propose that nuclear abnormalities causing premature aging in Zmpste24(-/-) mice trigger a metabolic response involving the activation of autophagy. However, the chronic activation of this catabolic pathway may turn an originally intended pro-survival strategy into a pro-aging mechanism and could contribute to the systemic degeneration and weakening observed in these progeroid mice.
|
| Volume |
17(14)
|
| Pages |
2196-211
|
| Published |
2008-7-15
|
| DOI |
10.1093/hmg/ddn120
|
| PII |
ddn120
|
| PMID |
18443001
|
| MeSH |
AMP-Activated Protein Kinase Kinases
AMP-Activated Protein Kinases
Aging, Premature / genetics
Aging, Premature / physiopathology*
Animals
Autophagy*
Disease Models, Animal
Glucose / metabolism
Hormones / blood
Humans
Lipid Metabolism
Membrane Proteins / genetics
Membrane Proteins / metabolism*
Metalloendopeptidases / genetics
Metalloendopeptidases / metabolism*
Mice
Mice, Transgenic
Microtubule-Associated Proteins / genetics
Microtubule-Associated Proteins / metabolism
Nuclear Receptor Subfamily 1, Group F, Member 3
Progeria / genetics
Progeria / physiopathology*
Protein Kinases / genetics
Protein Kinases / metabolism
Protein Serine-Threonine Kinases / genetics
Protein Serine-Threonine Kinases / metabolism
Receptors, Retinoic Acid / genetics
Receptors, Retinoic Acid / metabolism
Receptors, Thyroid Hormone / genetics
Receptors, Thyroid Hormone / metabolism
Signal Transduction
|
| IF |
5.101
|
| Times Cited |
110
|
|
WOS Category
|
GENETICS & HEREDITY
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| Resource |
| Mice |
RBRC00806 |
