論文 - 詳細
| RRC ID | 57111 |
|---|---|
| 著者 | Cosolo A, Jaiswal J, Csordás G, Grass I, Uhlirova M, Classen AK. |
| タイトル | JNK-dependent cell cycle stalling in G2 promotes survival and senescence-like phenotypes in tissue stress. |
| ジャーナル | Elife |
| Abstract |
The restoration of homeostasis after tissue damage relies on proper spatial-temporal control of damage-induced apoptosis and compensatory proliferation. In Drosophila imaginal discs these processes are coordinated by the stress response pathway JNK. We demonstrate that JNK signaling induces a dose-dependent extension of G2 in tissue damage and tumors, resulting in either transient stalling or a prolonged but reversible cell cycle arrest. G2-stalling is mediated by downregulation of the G2/M-specific phosphatase String(Stg)/Cdc25. Ectopic expression of stg is sufficient to suppress G2-stalling and reveals roles for stalling in survival, proliferation and paracrine signaling. G2-stalling protects cells from JNK-induced apoptosis, but under chronic conditions, reduces proliferative potential of JNK-signaling cells while promoting non-autonomous proliferation. Thus, transient cell cycle stalling in G2 has key roles in wound healing but becomes detrimental upon chronic JNK overstimulation, with important implications for chronic wound healing pathologies or tumorigenic transformation. |
| 巻・号 | 8 |
| 公開日 | 2019-2-8 |
| DOI | 10.7554/eLife.41036 |
| PII | 41036 |
| PMID | 30735120 |
| PMC | PMC6389326 |
| MeSH | Animals Apoptosis / genetics Carcinogenesis / genetics Cell Cycle Checkpoints / genetics Cell Division / genetics Cell Proliferation / genetics Cellular Senescence / genetics* Drosophila melanogaster / genetics Drosophila melanogaster / growth & development G2 Phase Cell Cycle Checkpoints / genetics Humans Imaginal Discs / growth & development Imaginal Discs / injuries Imaginal Discs / metabolism* JNK Mitogen-Activated Protein Kinases / genetics* MAP Kinase Signaling System / genetics Stress, Physiological / genetics* Wound Healing / genetics |
| IF | 7.551 |
| 引用数 | 7 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 6 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#111872 |