論文 - 詳細
| RRC ID | 5818 |
|---|---|
| 著者 | Inuzuka T, Tsuda M, Kawaguchi H, Ohba Y. |
| タイトル | Transcription factor 8 activates R-Ras to regulate angiogenesis. |
| ジャーナル | Biochem Biophys Res Commun |
| Abstract |
We have recently reported that transcription factor 8 (TCF8) negatively regulates pathological angiogenesis by regulating endothelial invasiveness by acting as a transcriptional attenuator of matrix metalloproteinase 1. TCF8 also modulates cell-matrix and cell-cell adhesion; however molecular mechanism of this TCF8 function remains obscure. Here, we provide evidence that TCF8 activates R-Ras, another class of angiogenic regulator, to suppress angiogenesis by a mechanism other than a transcriptional attenuator. Tube formation by human umbilical vein endothelial cells (HUVECs) facilitated by TCF8 suppression was significantly inhibited by the expression of constitutive active mutant of R-Ras. When we examined the mRNA expression levels of R-Ras regulators, no significant changes were observed to explain the R-Ras activation by TCF8. Interestingly, we found that TCF8 bound to CalDAG-GEFIII, an R-Ras activator, in the cytosol, indicating that TCF8 emanates signaling for R-Ras activation from cytosol to regulate angiogenesis negatively. |
| 巻・号 | 379(2) |
| ページ | 510-3 |
| 公開日 | 2009-2-6 |
| DOI | 10.1016/j.bbrc.2008.12.101 |
| PII | S0006-291X(08)02508-4 |
| PMID | 19116136 |
| MeSH | Cells, Cultured Endothelium, Vascular / cytology Endothelium, Vascular / enzymology Enzyme Activation Guanine Nucleotide Exchange Factors / metabolism Homeodomain Proteins / genetics Homeodomain Proteins / metabolism* Humans Mutation Neovascularization, Physiologic* / genetics Signal Transduction Transcription Factors / genetics Transcription Factors / metabolism* Umbilical Veins / cytology Umbilical Veins / enzymology Zinc Finger E-box-Binding Homeobox 1 ras Guanine Nucleotide Exchange Factors ras Proteins / genetics ras Proteins / metabolism* |
| IF | 2.985 |
| 引用数 | 23 |
| WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 遺伝子材料 | pCMV-VSV-G-RSV-REV (RDB04393) |