論文 - 詳細
| RRC ID | 59323 |
|---|---|
| 著者 | Burton NO, Dwivedi VK, Burkhart KB, Kaplan REW, Baugh LR, Horvitz HR. |
| タイトル | Neurohormonal signaling via a sulfotransferase antagonizes insulin-like signaling to regulate a Caenorhabditis elegans stress response. |
| ジャーナル | Nat Commun |
| Abstract |
Insulin and insulin-like signaling regulates a broad spectrum of growth and metabolic responses to a variety of internal and environmental stimuli. For example, the inhibition of insulin-like signaling in C. elegans mediates its response to both osmotic stress and starvation. We report that in response to osmotic stress the cytosolic sulfotransferase SSU-1 antagonizes insulin-like signaling and promotes developmental arrest. Both SSU-1 and the DAF-16 FOXO transcription factor, which is activated when insulin signaling is low, are needed to drive specific responses to reduced insulin-like signaling. We demonstrate that SSU-1 functions in a single pair of sensory neurons to control intercellular signaling via the nuclear hormone receptor NHR-1 and promote both the specific transcriptional response to osmotic stress and altered lysophosphatidylcholine metabolism. Our results show the requirement of a sulfotransferase-nuclear hormone receptor neurohormonal signaling pathway for some but not all consequences of reduced insulin-like signaling. |
| 巻・号 | 9(1) |
| ページ | 5152 |
| 公開日 | 2018-12-4 |
| DOI | 10.1038/s41467-018-07640-w |
| PII | 10.1038/s41467-018-07640-w |
| PMID | 30514845 |
| PMC | PMC6279808 |
| MeSH | Animals Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / antagonists & inhibitors Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Cloning, Molecular Embryo, Nonmammalian Embryonic Development / genetics Forkhead Transcription Factors / antagonists & inhibitors Forkhead Transcription Factors / metabolism Gene Expression Regulation, Developmental Insulin / metabolism Lysophosphatidylcholines / metabolism Mutagenesis Nerve Tissue Proteins / drug effects* Neurotransmitter Agents / metabolism* Osmotic Pressure RNA, Messenger / biosynthesis RNA, Messenger / genetics Receptor, Insulin / drug effects* Receptor, Insulin / metabolism Receptors, Cytoplasmic and Nuclear / metabolism Sensory Receptor Cells / drug effects Signal Transduction / drug effects* Signal Transduction / physiology* Starvation Stress, Physiological Sulfotransferases / antagonists & inhibitors* Sulfotransferases / genetics Sulfotransferases / metabolism |
| IF | 11.878 |
| 引用数 | 4 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 12 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1117 |