RRC ID 59323
Author Burton NO, Dwivedi VK, Burkhart KB, Kaplan REW, Baugh LR, Horvitz HR.
Title Neurohormonal signaling via a sulfotransferase antagonizes insulin-like signaling to regulate a Caenorhabditis elegans stress response.
Journal Nat Commun
Abstract Insulin and insulin-like signaling regulates a broad spectrum of growth and metabolic responses to a variety of internal and environmental stimuli. For example, the inhibition of insulin-like signaling in C. elegans mediates its response to both osmotic stress and starvation. We report that in response to osmotic stress the cytosolic sulfotransferase SSU-1 antagonizes insulin-like signaling and promotes developmental arrest. Both SSU-1 and the DAF-16 FOXO transcription factor, which is activated when insulin signaling is low, are needed to drive specific responses to reduced insulin-like signaling. We demonstrate that SSU-1 functions in a single pair of sensory neurons to control intercellular signaling via the nuclear hormone receptor NHR-1 and promote both the specific transcriptional response to osmotic stress and altered lysophosphatidylcholine metabolism. Our results show the requirement of a sulfotransferase-nuclear hormone receptor neurohormonal signaling pathway for some but not all consequences of reduced insulin-like signaling.
Volume 9(1)
Pages 5152
Published 2018-12-4
DOI 10.1038/s41467-018-07640-w
PII 10.1038/s41467-018-07640-w
PMID 30514845
PMC PMC6279808
MeSH Animals Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / antagonists & inhibitors Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Cloning, Molecular Embryo, Nonmammalian Embryonic Development / genetics Forkhead Transcription Factors / antagonists & inhibitors Forkhead Transcription Factors / metabolism Gene Expression Regulation, Developmental Insulin / metabolism Lysophosphatidylcholines / metabolism Mutagenesis Nerve Tissue Proteins / drug effects* Neurotransmitter Agents / metabolism* Osmotic Pressure RNA, Messenger / biosynthesis RNA, Messenger / genetics Receptor, Insulin / drug effects* Receptor, Insulin / metabolism Receptors, Cytoplasmic and Nuclear / metabolism Sensory Receptor Cells / drug effects Signal Transduction / drug effects* Signal Transduction / physiology* Starvation Stress, Physiological Sulfotransferases / antagonists & inhibitors* Sulfotransferases / genetics Sulfotransferases / metabolism
IF 11.878
Times Cited 4
C.elegans tm1117