| RRC ID |
61139
|
| 著者 |
Mitsuishi M, Miyashita K, Muraki A, Tamaki M, Tanaka K, Itoh H.
|
| タイトル |
Dietary protein decreases exercise endurance through rapamycin-sensitive suppression of muscle mitochondria.
|
| ジャーナル |
Am J Physiol Endocrinol Metab
|
| Abstract |
Loss of physical performance is linked not only to decreased activity in daily life but also to increased onset of cardiovascular diseases and mortality. A high-protein diet is recommended for aged individuals in order to preserve muscle mass; however, the regulation of muscle mitochondria by dietary protein has not been clarified. We investigated the long-term effects of a high-protein diet on muscle properties, focusing especially on muscle mitochondria. Mice were fed a high-protein diet from the age of 8 wk and examined for mitochondrial properties and exercise endurance at the ages of 20 and 50 wk. Compared with normal chow, a high-protein diet significantly decreased the amount of muscle mitochondria, mitochondrial activity, and running distance at 50 wk, although it increased muscle mass and grip power. Inhibition of TORC1-dependent signal pathways by rapamycin from 8 wk suppressed the decline in mitochondria and exercise endurance observed when mice were fed the high-protein diet in association with preserved AMPK activity. Collectively, these findings suggest a role for dietary protein as a suppressor of muscle mitochondria and indicate that the age-associated decline in exercise endurance might be accelerated by excessive dietary protein through rapamycin-sensitive suppression of muscle mitochondria.
|
| 巻・号 |
305(7)
|
| ページ |
E776-84
|
| 公開日 |
2013-10-1
|
| DOI |
10.1152/ajpendo.00145.2013
|
| PII |
ajpendo.00145.2013
|
| PMID |
23880314
|
| MeSH |
Animals
Cell Line
Dietary Proteins / metabolism*
Energy Metabolism / drug effects
Energy Metabolism / physiology
Hand Strength / physiology
Mechanistic Target of Rapamycin Complex 1
Mice
Mice, Inbred C57BL
Mitochondria, Muscle / drug effects
Mitochondria, Muscle / metabolism*
Multiprotein Complexes / metabolism
Muscle, Skeletal / drug effects
Muscle, Skeletal / metabolism*
Physical Conditioning, Animal / physiology*
Physical Endurance / drug effects
Physical Endurance / physiology*
Signal Transduction / drug effects
Signal Transduction / physiology
Sirolimus / pharmacology
TOR Serine-Threonine Kinases / metabolism
|
| IF |
3.469
|
| リソース情報 |
| ヒト・動物細胞 |
C2C12(RCB0987) |
